摘要
目的探讨脑脊液补体C3,C4及C-反应蛋白(C-reactive protein,CRP)检测,对中枢神经系统感染患者病因的鉴别诊断意义及脑脊液补体C3,C4与血清补体C3,C4的关系。方法采用速率散射比浊法测定38例病毒性脑炎(A组)、10例化脓性脑膜炎(B组)、18例结核性脑膜炎(C组)及22例非中枢神经系统感染(对照组)患者脑脊液及血清补体C3,C4及C-反应蛋白含量,并进行对比分析。结果1B组、C组、A组、对照组脑脊液C3阳性率分别为100.00%,88.88%,5.20%,0;脑脊液C4阳性率分别为80.00%,44.44%,0,0。B组、C组与A组及对照组脑脊液C3,C4比较,差异有显著意义(P<0.01);C组与B组、A组及对照组脑脊液C3,C4比较,差异无显著意义(P>0.05);2血清C3,C4检测结果显示,各组均在正常参考范围内,组间比较,差异无显著意义(P>0.05),与同组脑脊液C3,C4无正相关。3B组、C组脑脊液CRP值和血清CRP值与A组及对照组比较,显著增高(P<0.01);B组与C组比较,差异无显著意义(P>0.05);A组与对照组比较,差异无显著意义(P>0.05)。结论脑脊液补体C3,C4,CRP及血清CRP值,对细菌性脑膜炎与病毒性脑炎的鉴别诊断有很高的参考价值。脑脊液补体C3,C4与血清中补体C3,C4无明显相关性。
Objective To clarify the meaning of distinguish and diagnose the pathogensis about children＇s central nervous system infection （CNSI） through assaying the content of C3,C4 and C-reactive protein （CRP） in cerebrospinal fluid （CSF） and the relationship of complement C3,C4 in CSF and serum of CNSI. Methods Use the rate nephelometry assay the patients＇ complement C3,C4 and CRP in CSF and serum which existed in 38 cases of virus meningitis （VM） （group A）, 10 cases of purulent meningitis （PM） （group B）,18 cases of tubercular meningitis （TM） （group C） and 22 cases of non-central nerve system infection（NCNSI） （control group）. Results①The positive rate of C3 in CSF is 100%,88.88%, 5.20% and 0 in group B, C,A and control group respectively. And C4 in CSF is 80.00 %,44.44 %,0 and 0 respectively. There is a significant difference between group B, C, A and control group （P〈0. 01）. No significant difference was found between group C and B, also A and control group （P〉0. 05）. ② The assay results of C3 and C4 in serum is in normal reference range. The comparison between two groups had no significant difference （P〉 0. 05）. There is no positive correlation between C3, C4 in CSF and C3,C4 in serum in the same group. ③The value of CRP in CSF and serum group B and C is higher than that of A and control group （P〈0.01）. No significant difference was found between group B and C. Also there is no significant difference between group A and control group （P〉0.05）. Conclusion Complement C3,C4, CRP in CSF and CRP in serum have high referenced value upon distinguish and diagnose the virus meningitis and bacterial meningitis. Complement C3 ,C4 in CSF and complement C3 ,C4 in serum do not have significant relevance.
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2007年第5期261-263,共3页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词
中枢神经系统
感染
脑脊液
血清
补体C3
C4
C-反应蛋白
central nervous system
infection
cerebrospinal fluid
serum
complement C3, C4
C-reactive protein （CRP）
