摘要
对7例患者肾移植术后并发重症病毒性肝炎的病回进行了分析。发现所有患者均为HBSAg阳性的HBV感染者，2例重叠HCV感染，HAV和HDV重叠感染各1例。表明HBV感染及在此基础上其它肝炎病毒合并感染是发生重症肝炎的主要原因；治疗过程中环孢素A的应用和它所引起的肝肾毒性是移植后重症肝炎发生和影响患者预后的一个重要因素。提出应慎重考虑HBV感染者的肾移植适应症，有HCV、HDV重叠感染者不宜施行肾移植术。对HBsAg阳性肾移植患者应加强术后肝功能的监测，及早应用保肝药物。
There were 7 cases of renal allograft recipients developing sub-acute fulminant hepatitis.In order to investigate the etiological agents, we examined serological markers of hepatitides A, B, C,and D. It was found that all patients were HBsAgpositive, 2 of 7 cases were superinfection of HCV,one each was HAV and HDV. It is suggested thaton the basis of HBV infection superinfection of HCV, HDV, HAV, and other hepatitis viruses were very important causes of the fulminant hepatitis in the renal allograft recipients. In the otherhand, according to clinical feature and other studyresults, hepatotoxicity and nephrotoxicity of cyclosporine A was another main development factorof fulminant hepatitis. Finally, this paper also recommends some preventive methods and suggestions.
出处
《西安医科大学学报》
CSCD
1997年第1期79-80,88,共3页
Journal of Xi'an Medical University(Chinese)
关键词
肾移植
手术后
病毒性肝炎
病因
etiology
fulminant hepatitis
renal allograft recipient
hepatitis virus
