摘要
通过给予大鼠外源性哇巴因，观察其对血压的影响，并同地高辛进行对比研究，发现长期给予小剂量哇巴因可引起大鼠血压明显升高，而地高辛无此作用，间接证明了内源性类洋地黄物质即是哇巴因而非地高辛，同时说明哇巴因是导致血压升高的原因之一，而非其继发性的结果，并为哇巴因与高血压的研究提供了一种新的动物模型：哇巴因-高血压鼠。
We administered ouabain to normotensive rats to observe its effect on blood pressure and compare with that of digoxin. The resultsshowed that ouabain, with small dose chronically,produced hypertension significantly, and digoxin didnot. It Droved indirectly that endogenous diuitalislike factor was ouabain, not digoxin, and it was oneof the causes of hypertension, but not secondary effect on hypertension. Also, we supplied a new model for the research of ouabain and hypertension:ouabain-hypertension rats in this study.
出处
《西安医科大学学报》
CSCD
1997年第1期24-26,共3页
Journal of Xi'an Medical University(Chinese)
