摘要
研究了家蝇Musca domestica幼虫提取物对辐射小鼠的免疫调节作用。测定了小鼠的脏器官指数,NK细胞活性,T、B淋巴细胞增值活性及小鼠血清SOD活性和MDA含量等指标。结果表明:经口给予一定剂量的家蝇幼虫提取物对辐射和未辐射小鼠的脾脏指数和胸腺指数变化有显著影响,均可提高NK细胞活性,T、B淋巴细胞增值活性及小鼠血清SOD活性,同时可降低小鼠血清中的MDA含量。结果显示家蝇幼虫提取物对辐射和未辐射小鼠均具有较好的免疫调节作用。
The immunomodulatory effects of the extract of housefly Musca domestica larvae on irradiated Kunming mice were studied with such indices as the viscera indices, the activity of NK cell, the proliferation of T and B lymphocyte, SOD activity and MDA content assayed. The results indicated that the treatment with the extract consecutively for 18 d increased the mice＇ Spleen and Thymus indices, the activity of natural killer cell, and the proliferation of T, B lymphocyte. Serum analysis demonstrated that the extract significantly reduced the content of MDA and increased the activity of SOD. The results suggest that the extract of housefly larvae has positive immunomodulatory effects on mice irradiated or not.
出处
《昆虫学报》
CAS
CSCD
北大核心
2007年第9期889-894,共6页
Acta Entomologica Sinica
基金
"十一五"国家科技支撑计划项目(2006BAD06B07)
关键词
家蝇
幼虫提取物
辐射小鼠
免疫调节
抗氧化
Musca domestica
larvae extract
irradiated mice
immunomodulation
antioxidation
