摘要
应用免疫印迹技术测定５２例皮肌炎和多发性肌炎病人血清可提取性核抗原（ＥＮＡ）多肽抗体，其中Ｊｏ－１抗体的阳性率分别为１３．３％和３１．８％。１１例Ｊｏ－１抗体阳性病人中７２．７％起病较急，对类固醇治疗反应差，减药或停药易于复发；４５．５％伴发间质性肺病，５４．５％伴有Ｒａｙｎａｕｄ现象，６３．６％合并关节炎，３６．４％合并恶性肿瘤。４１例Ｊｏ－１抗体阴性病人上述合并症阳性率仅分别为９．８％、１７．１％、１９．５％和１４．６％。抗合成酶抗体可能是引起组织损伤的直接因素。
The ENA polypeptide in sera of 52 patients with dermatomyositis(DM)/polymyositis(PM) were measured by immunoblotting technique, the positive rate of Jo 1 antibody is 13.3% and 31.8% respectively. In the 11 patients with positive Jo 1 antibody, 8 cases (72.7%) have a more raped onset, respond less completely to corticosteroid treatment and more often have recurrences as treatment is withdrawn, 5 cases (45.5%) have interstitial pulmonary disease, 6 cases (54.5%) have Raynaud′s phenomenon, 7cases (63.6%) have arthritis and 4 cases (36.4%) have malignancy. In the 41 patientis with negative Jo 1 antibody, the frequency of ILD, RP, arthritis and malignancy is 9.8%, 17.1%, 19.5%, and 14.6% respectively. The anti synthetases antibodyies may be a direct factor by which the tissue damage develops.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1997年第2期81-83,共3页
Journal of Clinical Dermatology
关键词
皮肌炎
多发性肌炎
Jo-1抗体
测定
Dermatomyositis Polymyositis Jo 1 antibody antisynthetase syndrome
