摘要
对米非司酮配伍卡前列甲酯栓(PG05)或米索前列醇(米索)用于120例孕10～16周妊娠妇女(随机分为四组)进行了终止妊娠效果的观察。对象一次或分次服米非司酮200mg后48小时,分别使用米索(Ⅰ、Ⅱ组)或PG05(Ⅲ、Ⅳ组),有效率分别为80.0％、80.0％、96.7％、100％。伍用PG05效果明显优于伍用米索。引流产时间分别为5.79、6.54、5.53、6.49小时,四组间无差异。Ⅲ、Ⅳ组副反应高于Ⅰ、Ⅱ组。结论:米非司酮200mg配伍PG05或米索是终止孕10～16周妊娠安全有效的方法。观察中PG05的效果高于米索,考虑可能与米索的剂量偏低有关。由于存在不全流产率较高及潜在的子宫破裂、宫颈裂伤危险,终止妊娠需加强监护。
Objective: To evaluate the efficacy of mifepris-tone (MIF) in combination with prostaglandins in termination of 10~16 gestational weeks of pregnancy. Methods: 120 women of 10~ 16 gestational weeks of pregnancies were recruited. They were randomly allocated into 4 groups :Group 1 and 3,MIF 50mg q. 12. h ×4; group 2 and 4, MIF 200 mg in a single dose. Then in the morning of the third day oral miso-prostol 400ftg were given every 4 hours for 2 times in group 1 and 2; while PG05 1mg vaginal suppository was used q. 2. h for a maximum of 5 mg in group 3 and 4. Results; The success rates were 80% , 80% . 96. 7% and 100% respectively, which showed a significant difference between the use of misoprostol and PG05(P<0. 05). The average induce-abortion time intervals were 5. 79.6. 54,5. 53 and 6. 49 hours respectively, and there were no significant difference. Side effects associated with PG05 were slightly higher in the PG05 groups. Conclusion: MIF 200 mg in combination with PG05 is a safe and effective method for termination of 10~ 16 gestational weeks of pregnancy. The lower success rates observed in the misoprostol groups might be related to the less dose used. Due to the potential risks of incomplete abortion and laceration of cervix or rupture of uterus,close monitoring during the process of abortion must be emphasized.
出处
《中国计划生育学杂志》
1997年第2期89-91,共3页
Chinese Journal of Family Planning
关键词
终止妊娠
米非司酮
前列腺素
Mifpristone PG05 Misopostol Pregnancy termination
