摘要
目的通过分析原发性胆汁性肝硬化患者的临床资料,旨在提高对该病的诊治水平。方法对25例原发性胆汁性肝硬化患者的临床和病理资料进行回顾性分析,总结患者的临床特征、各项生化指标、免疫学与病理学特点。结果在25例PBC患者,ALP均明显升高(524.9±214.4U/L),17例γ-GT升高(431.1±248.9U/L),8例总胆红素升高(274.1±161.6μmol/L),均以直接胆红素升高为主,21例抗核抗体(ANA)阳性;12例行肝穿刺病理检查,其中11例符合PBC;8例影像学检查显示肝内胆管扩张,走行僵直。结论PBC主要累及中老年女性,血清ALP、γ-GT水平升高,AMA阳性以及病理学与影像学检查有助于诊断本病。
Objective To investigate the clinical and pathological findings in patients with primary biliary cirrhosis in order to improve the diagnosis and management of the disease. Methods 25 patients with PBC were reviewed as respect to the clinical, biochemical, immunological, pathological and radiographic features. Results ALP, GGT and TBA levels were markedly elevated in the majority of the patients. 21 cases were positive for AMA. Liver biopsies in 12 patients indicated that 11 cases were in accordance with PBC. Radiographic findings revealed that bile ducts expanded and stiff. Conclusion PBC is mostly found in middle aged and old women. Elevated serum ALP,GGT levels together with AMA positive, liver biopsy and radiographic findings can help to diagnose PBC.
出处
《实用肝脏病杂志》
CAS
2007年第5期315-317,共3页
Journal of Practical Hepatology
