摘要
目的了解肝脏疾病患者院内真菌感染的抗菌药物应用情况,以探讨肝脏疾病患者院内真菌感染与抗生素应用之间的关系。方法应用回顾性调查方法对我院1986年1月至2006年6月发生院内真菌感染的507例肝脏疾病患者临床资料进行分析。结果真菌感染前有446例(87.97%)患者使用抗生素,使用抗菌药物最多的为第3代头孢菌素、氟喹诺酮类、青霉素类。在抗菌药物应用中存在用药起点高、联合用药者多,疗程过长或频繁换药,真菌感染后未及时停药等现象。结论肝脏疾病患者合并真菌感染后加重基础肝病,预后差。不合理使用抗生素与真菌感染密切相关。
Objective To investigate the relationship between nosocomial fungus infection in the in-patients with underlying severe liver diseases and antibiotic treatment. Methods 507 hospitalized cases of liver disease patients with nosocomial fungus infection from January 1985 to June 2006 were investigated and analyzed retrospectively. Results 446 cases（87. 97% ）were treated with antibiotics before diagnosed with fungal infection, and the most frequnently used antibiotics were the third generation of cephalosporins, fluoroquinolones, broad-spectrum penicillins. The related factors such as the combined use of antibiotics or the longer exposure to the same antibiotics or antibiotics changed frequently or continuous use of antibiotics after fungal infection were demonstrated. Conclusion The fungal infection would exacerbate the underlying liver diseases with the worse prognosis. Irrational use of antibiotics, which is closely related to the fungal infection, should be avoided in clinical practice.
出处
《实用肝脏病杂志》
CAS
2007年第5期306-308,共3页
Journal of Practical Hepatology
关键词
重症肝病
真菌
医院内感染
抗生素
Severe liver disease Fungus infection Nosocomial infection Antibiotics
