摘要
目的:研究含白木通龙胆泻肝丸对胆汁淤积大鼠的利胆保肝作用。方法:大鼠一次性灌胃给予100 mg·kg-1α-萘异硫氰酸酯(ANIT)花生油建立胆汁淤积模型。测定给药后0.5,1,1.5,2,3,4 h胆汁流量,血清AST、ALT、ALP、TBIL、DBIL、CHO、SOD、MDA、GSH水平,胆汁中TBIL、DBIL、CHO含量并观察肝组织病理变化。结果:含白木通的龙胆泻肝丸能显著增加ANIT致胆汁淤积大鼠的胆汁分泌量,并降低肝损伤及胆管损伤的程度,有降低血清TBIL、DBIL水平的趋势。但对模型大鼠血清ALT、AST、SOD、MDA、GSH水平无明显影响。结论:含白木通龙胆泻肝丸有一定的利胆保肝作用。
Objective：To investigate the cholagogic effect and hepatoprotective effect of Longdan Xiegan Pill on the Cholestasis model in mice. Methods-The cholestasis model was induced by percutaneous 100 mg·kg^-1 α-Naphthyl isothiocyanate（ ANIT）. Bile flow, the levels of AST, ALT, ALP, TBIL, DBIL, CHO, SOD, MDA, GSH inserum and TBIL, DBIL, CHO in the bile were measured. Pathological changes of the liver tissue were observed under opticmicroscope. Results：Longdan Xiegan Pill（with Caulis Akebiale Australis） significantly highered Bile flow and markedly ameliorated the liver damage （ P 〈 0.05 ）. Conclusion： Longdan Xiegan Pill （ with Caulis Akebial Australis ） can protect against cholestasis induced by ANIT in mice.
出处
《中国实验方剂学杂志》
CAS
2007年第10期37-40,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
龙胆泻肝丸
白木通
胆汁淤积
Longdan Xiegan Pill
Caulis Akebiale Australis
cholestasis
