摘要
目的:探讨125I放射粒子植入治疗复发性脑胶质瘤的技术方法、疗效和安全性。方法:33例手术或放疗后复发性脑胶质瘤患者行CT引导下125I粒子植入术,根据术前计划确定粒子数目、空间分布和粒子针数目。粒子活度为0.4～0.8mCi,间距为0.5～1.0cm,共植入粒子10～35颗,术后即刻行CT扫描并进行质量验证。术后定期复查CT。结果:按照WHO疗效评价标准,1、3和6个月时有效率分别为48.5%、67.7%和80.0%。全组中位生存期16个月,其中1～2级胶质瘤中位生存期26个月,3～4级胶质瘤中位生存期11个月;全组1年生存率为66.7%(22/33),其中1～2级胶质瘤1年生存率为85.0%(17/20),3～4级胶质瘤1年生存率为38.5%(5/13)。并发症包括针道少量出血4例,局部脑坏死5例。未出现与治疗相关的死亡病例。结论:CT引导125I粒子植入治疗复发性脑胶质瘤具有安全、微创、并发症少和疗效肯定等优点,值得进一步应用。
OBJECTIVE： To study the method, efficacy and safety of 125i seed implants for recurrent brain gliomas under CT guidance. MEHTODS： Thirty-three patients with recurrent brain gliomas after surgery or radiotherapy received ^125I seed implants. According to the preoperative plan, the number of particles, space distribution and number of needles were determined. The particle activity was 0.4-0.8 mCi and the distance from 0.5 to 1.0 cm, and 10-35 particles were implanted altogether. After the operaction the scanning was performed at once and the quality was tested. CT was repeated regularly after the operation. RESULTS： According to WHO evaluation criterion, the effective rates were 48.5%, 67.7% and 80.0%, respectively, at 1, 3 and 6 months. The median survival for the overall group was 16 months, 1 - 2 grade glioma, 26 months, 3-4 grade glioma, 11 months. Oneyear survival for overall group was 66.7%, 1- 2 grade glioma, 85.0%, 3-4 grade glioma, 38.5%. The complications included small amount bleeding from needle channel（4 cases）, local brain necrosis（5 cases）. There were no treatment related death cases. CONCLUSIONS： 12si seed implants for recurrent brain gliomas under CT guidance is safe and microdamaged. It has low complications and definit effect and is worth for application further.
出处
《中华肿瘤防治杂志》
CAS
2007年第22期1714-1716,共3页
Chinese Journal of Cancer Prevention and Treatment
