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糖尿病与肝细胞癌患病危险关系的回顾性研究 被引量:5

Retrospective study on diabetes mellitus and the risk of hepatocellular carcinoma
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摘要 目的:研究糖尿病(diabetes mellitus,DM)与肝细胞癌(hepatocellularcar cinoma,HCC)患病的关系。方法:采用病例对照的方法,回顾性分析同期住院的HCC患者和其他非肿瘤疾病患者患DM的情况,以及乙型肝炎史、体质量指数、血脂水平、乙醇摄入和吸烟等方面的差异。结果:HCC组中,DM患者罹患HCC的危险度是非DM患者的1.83倍(95%CI:1.15~2.91;P≈0.01);多因素分析显示DM是HCC患病的独立危险因素(OR=1.87;95%CI:1.21~2.93)。结论:DM与HCC存在一定的相关性,DM患者罹患原发性肝癌的风险增高。 OBJECTIVE: To study the relationship between diabetes mellitus (DM) and hepatocellular carcinoma (HCC). METHODS: A hospital-based casecontrol study was conducted on patients with HCC and controls without neoplastic diseases. RESULTS: DM was associated with HCC, and the odd ratio was 1.83 (95%CI: 1.15-2.91; P≈0.01). Multivariate logistic regression analysis showed that DM was an independent factor to HCC(OR=1. 87;95%0CI:1. 21-2. 93). CONCLUSION: Patients with DM are at an increased risk of HCC.
出处 《中华肿瘤防治杂志》 CAS 2007年第22期1685-1686,共2页 Chinese Journal of Cancer Prevention and Treatment
关键词 糖尿病 肝细胞 回顾性研究 diabetes mellitus carcinoma, hepatocellular retrospective study
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参考文献5

  • 1Lu S N, Lin T M, Chen C J, et al. A case control study of primary hepatocellular carcinoma in Taiwan[J]. Cancer, 1988,62 (9) :2051-2055.
  • 2Hassan M, Hwang L, Hatten C,et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus[J]. Hepatology ,2002,36(5) : 1206-1213.
  • 3Davila J A, Morgan R O, Shaib Y, et al. Diabetes increases the risk of hepatocellular carcinoma in the United States: a popula- tion based control study[J]. Gut, 2005, 54(4),533-539.
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