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他汀类药物对心肌梗死后心室重构的作用 被引量：2

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摘要 心肌梗死后心室重构是指急性心肌梗死后心室大小、形态、组织结构及功能状态的改变，是心梗发展为心衰的重要病理生理过程。预防急性心肌梗死后心室重构是心力衰竭防治不容忽视的一个重要环节。最新的研究显示，他汀类药物具有抑制心肌梗死后心室重构，改善左室功能的作用。
作者 何文静 张英杰
机构地区 辽宁医学院附属第一医院心内科
出处 《中国心血管病研究》 CAS 2007年第10期791-793,共3页 Chinese Journal of Cardiovascular Research
关键词 急性心肌梗死后 心室重构 他汀类药物 病理生理过程 组织结构 心力衰竭 左室功能
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

  • 1[1]Hayashidani S,Tsutsui H,Shiomi T,et al.Fluvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.attenuates left ventricular remodeling and failure after experimental myocardial infarction.Circulation,2002,105:868-873.
  • 2[2]Bauersachs J,Galuppo P,Fraccarollo D,et al.Improvement of left ventricular remodeling and function by hydroxymethyglutaryl coenzyme A reduetase inhibition with cerivastatin in rats with heart failure after myocardial infarction.Circulation,2001,104:982-985.
  • 3[3]Nahrendorf M,Hu K,Hilter KH,et al.Impact of hydroxymethylglutaryl coenzyme a reduetase inhibition on left ventricular remodeling after myocardial infarction:an experimental serial cardiac magnetic resonance imaging study.J Am Coil Cardiol,2002,40:1695-1700.
  • 4[4]Ohara Y,Hiasa Y,Ho so kawa S,et al.Impact of hydroxymethylglutaryl eoenzyme A reductase inhibition on left ventricular remodeling in patients with acute anterior myocardial infarction after primary coronary angioplasty.Int Heart J,2005,46:987-995.
  • 5[5]Martin J,Denver R,Bailey M,et al.In vitro inhibitory effects of atorvastatin on cardiac fibroblasts:implications for ventricular remodelling.Clin Exp Pharmacol Physiol,2005,32:697-701.
  • 6[6]Saitoh T,Nakajima T,Kawahara K.Possible involvement of apoptotic death of myocytes in left ventrieular remodeling after myocardial infarction.Jpn J Physiol,2003,53:247-252.
  • 7[7]Bergmann MW,Reehner C,Freund C,et al.Statins inhibit reoxygenation-induced cardiomyocyte apoptosis:role for glycogen synthase kinase beta and transcription factor beta-catenin.J Mol Cell Cardiol,2004,37:681.
  • 8[8]Ito M,Adachi T,Pimentel DR,et al.Statins inhibit beta-adrenergic receptor-stinmlated apoptosis in adult rat ventricular myocytes via a Racl-dependent mechanism.Circulation,2004,110:412-418.
  • 9[9]Koichi T,Masaaki H,Toshikazu T.Anti-apoptotic efect of atorvastatin a 3-Hydroxy-3-methylglutaryl coenzyme A reductasc inhibitor.on cardiac myocytes throush protein kinase C activation.Clin Exp Pharmacol Physiol,2004,31:360-367.
  • 10[10]Indolfi C,Di Lorenzo E,Perrieno C,et al.Hydroxy-methylglutaryl coenzyme A reductase inhibitior simvastatin Prevents cardiac hypertrophy induced by pressyre overload and inhibits p21ras activation.Circulation,2002,106:2118-2124.

二级参考文献10

  • 1[1]Conrad CH,Brooks WW,Hayes JA,et al.Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat[J].Circulation,1995,91(1):161-8
  • 2[2]Querejeta R,López B,Gonzá1ez A,et al.Increased collagen type Ⅰ synthesis in patients with heart failure of hypertensive origin:relation to myocardial fibrosis[J].Circulation,2004,110:1263-8.
  • 3[3]LIPID Study Group.Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations:the LIPID trial follow-up[J].Lancet,2002,359(9315):1379-87.
  • 4[4]Balk EM,Karas RH,Jordan HS,et al.Effects of statins on vascular structure and function:a systematic review[J].Am J Med,2004,117(10):775-90.
  • 5[5]Onishi,K Dohi K,Koji T,et al.Candesartan prevents myocardial fibrosis during progression of congestive heart failure[J].J Cardiovasc Pharmacol,2004,43(6):860-7.
  • 6[6]Misono K,Ogawa H,Qiu Y,et al.ANP receptor structure and signal transduction mechanism:a novel hormone-induced rotation mechanism for transmembrane signaling[J].Tanpakushitsu Kakusan Koso,2005,50(9):1078-87.
  • 7[9]Rogler G,Lackner KJ,Schmitz G.Mevalonate is essential for growth of porcine and human vascular smooth muscle cells in vitro[J].Basic Res Cardiol,1995,90:443-7.
  • 8[10]Thompson K,Rojas J,Rogers J.Alkylamines cause V 9V 2 T-cell activation and proliferation by inhibiting the mevalonate pathway[J].Blood,2005,10:1182-95.
  • 9[11]Laufs U,Marra D,Node K,et al.3-hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of P27kip 1[J].J Biochem,1999,274:21926-31.
  • 10[12]Wadhwa R,Yaguchi T,Hasan MK.Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation[J].Biochem Biophys Res Commun,2003,302(4):735-42.

共引文献9

同被引文献37

  • 1谭茗月,李安莹,赵水平,申文宇,王东侠.心力衰竭患者血浆中细胞凋亡抑制因子和细胞因子的变化以及阿托伐他汀的干预作用[J].临床心血管病杂志,2007,23(2):97-100. 被引量：12
  • 2赵桂琴,吴国球,刘乃丰.心肌肌钙蛋白I异常病人血清结缔组织生长因子表达的研究[J].东南大学学报（医学版）,2007,26(3):166-169. 被引量：1
  • 3丁荣晶.曲美他嗪改善慢性心力衰竭患者的内皮功能与抗氧化作用有关[J].中国心血管病研究,2007,5(10):800-800. 被引量：1
  • 4NISHIOKA T,SUZUKI M,ONISHI K,et al.Eplerenone attenuatesm yocardial fibrosis in the angiotensin Ⅱ-induced hypertensive mouse:involvement of tenascin-C induced by aldosterone-mediated inflammation[J].J Cardiovasc Pharmacol,2007,49(5):261-268.
  • 5ANDRAE J,GALLINI R,BETSHOLTZ C.Role of platelet-derived growth factors in physiology and medicine[J].Genes Dev,2008,22(10):1276-1312.
  • 6TAKANO H,ZOU,Y,HASEGAWA H,et al.Oxidative stress-induced signal transduction pathways in cardiac myocytes:involvement of ROS in heart diseases[J].Antioxid Redox Signal,2003,5(6):789-794.
  • 7YASUNARI K,MAEDA K,MINAMI M,et al.HMG-CoA reductase inhibitors pre-vent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress[J].Arterioscler Thromb Vasc Biol,2001,21:937-942.
  • 8CASTRO C,DIEZ-JUAN A,CORTES,M J,et al.Distinct regulation of mitogen-activated protein kinases and p27Kip1 in smooth muscle cells from different vascular beds.A potential role in establishing regional phenotypic variance[J].Biol Chem,2003,278:4482-4490.
  • 9TEA B S,DAM T V,MOREAU P,et al.Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats.Temporal regulation and spatial heterogeneity[J].Hyper-tension,1999,34(2):229-235.
  • 10BUEMI M,CORICA F,MARINO D,et al.Cardiovascular remodeling,apoptosis,and drugs[J].Am J Hypertens,2000,13:450-454.

引证文献2

二级引证文献17

中国心血管病研究
2007年 第10期

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