摘要
将湿法工艺合成的β-磷酸钙纳米粒子与左旋聚乳酸（PLLA）的混合溶液通过电纺丝法制成杂化纳米纤维膜，以期制备一种新型纳米纤维骨组织修复材料。采用FT-IR，XRD，TEM，DSC等手段研究了β-磷酸钙（β-TCP）的结构和形态，采用SEM和直径分布探讨了优化PLLA／β-TCP纤维的电纺丝工艺。结果表明：采用湿法合成β-TCP的纳米粒子具有良好的晶型结构，直径在219～328nm之间；采用双溶剂体系在优化条件下制备的PLLA／β-TCP杂化纳米纤维直径在500～700nm之间，PLLA／β-TCP界面结合良好，β-TCP起到了增强作用。在湿态条件下，PLLA纤维膜的力学性能有所提高，而PLLA／β-TCP纤维膜的力学性能则呈现下降趋势。
β-Tricalcium phosphate （β-TCP） which synthesize by wet method and poly （L-lactic acid） （PLLA） hybrid membrane was fabricated via electrospinning of the PLLA/β-TCP dispersion for the applications in bone tissue regeneration. The structural properties and morphologies of β-TCP nanoparticles were investigated by FT-IR, XRD, TEM and XPS. The results showed that the diameters of β-TCP particles fall in the range from 219 to 328 nm and with good crystal structure. In order to optimize the technics of electrospinning, the effects of process parameters on the fiber morphology are studied by SEM and diameter distributing. PLLA/β-TCP nanofiber with the diameter from 500 to 700 nm can be produced via electrospinning under the optimium condition. The mechanical test result showed that PLLA/β-TCP membrane has a strong surface bonding and hightensile strength, the mechanical property of PLLA nonwoven has increased, but the mechanical property of PLLA/β-TCP nonwoven shows a downward trend, under wet conditions.
出处
《功能高分子学报》
CAS
CSCD
北大核心
2007年第3期277-285,共9页
Journal of Functional Polymers
基金
国家自然科学基金(30471907)
清华大学裕元医学基金(202400005.34)
关键词
Β-TCP
合成
杂化纤维
电纺丝
β-TCP
synthesize
hybrid membrane
electrospinning
