摘要
目的:探讨食管鳞癌组织中淋巴结微转移与淋巴结转移在分子水平的差异。方法:选取32例食管鳞癌患者手术中摘除纵隔淋巴结78枚(病理转移淋巴结25枚,无病理转移淋巴结53枚)行CK19表达。CK19表达阳性的无病理转移淋巴结作为A组,有病理转移淋巴结为B组。两组均行mtDNA表达的检测。结果:病理转移淋巴结CK19表达均阳性,无病理转移淋巴结CK19表达阳性18枚。A组5枚(5/18)淋巴结mtDNA表达阳性,B组17枚(17/25)淋巴结mtDNA表达阳性,χ2=6.82,P<0.05。结论:食管鳞癌淋巴结转移和淋巴结微转移在生物学特性有不同的表现。食管鳞癌淋巴结微转移不是淋巴结转移的早期,也不等同于淋巴结转移。
OBJECTIVE： To explore the difference between lymph node micrometastasis and metastasis in esophageal cancer. METHODS： Seventy eight mediastinal lymph nodes, including metastasis lymph nodes 25 and no metastasis lymph nodes 53, were selected for expressing CK19. Positive expression of CK19 of no metastasis lymph nodes were group A, while metastasis lymph nodes were group B. Both groups were to express mtDNA. RESULTS： The expression of CK19 in all metastasis lymph nodes was positive, while in no metastasis lymph nodes 18 were positive. The expression of mtDNA in group A, 5 were positive; while in group B, 17 were positive, χ^2=6.82,P〈0.05. CONCLUSION： There is a different biological feature between the lymph node micrometastasis and metastasis in esophageal cancer, which suggests that the lymph node micrometastasis in esophageal cancer is not the early stage of the lymph node metastasis and it is not the lymph node metastasis either.
出处
《中华肿瘤防治杂志》
CAS
2007年第19期1462-1464,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
癌
鳞状细胞/病理学
食管肿瘤/病理学
淋巴转移
分子生物学
carcinoma, squamous cell/pathology
esophageal neoplasms/pathology
lymphatic metastasis
molecular biology
