摘要
葡萄糖—6—磷酸脱氢酶(G6PD)缺乏症是一种主要表现溶血的遗传性代谢疾患,遗传方式为X连锁不完全显性遗传,具有不同的表现度。患者的G6PD活性或稳定性显著降低,溶血性贫血一般呈间歇性发作,但某些变异型可有慢性自发性溶血的表现。在G6PD众多的变异型中,有不少在服用蚕豆或伯氨喹啉类药物后,会诱发急性溶血。
A comparative investigation of visual acuity, color sensation, corneal sensitivity, lens and vitreous as well as ocular fund us were performed in two groups between the 57 cases of G6PD deficiency and 62 normal G6PD activity as controls in Chonghua, Guanndong, P. R. China——the high incidence area of G6PD deficiency. The results showed that the inciden ces of congenital lenticular opacities and congenital color blindness in G6PD deficiency group were higher than those in the controls. However, there were no signs of pale conjunctiva, sclera xanthochromia, pallor papillae and macular edema with favism. The hemoglobin values of all the cases were within normal range. It is indicated that the subjects with G6PD deficiency are usually not manifesting hemolysis but only a hereditary susceptibility. The ocular manifestations in favism are as a result of hemolysis, tissue anoxia and poisonous substances from Vicia faba.
出处
《广东医学》
CAS
CSCD
1990年第4期9-11,共3页
Guangdong Medical Journal
