摘要
本文观察３６５例非胰岛毒依赖型糖尿病（ＮＩＤＤＭ）人红细胞膜流动性，并探讨了膜流性与空腹血浆胰岛素（ＦＰＩ）、空腹血糖（ＦＢＧ）和糖化血红蛋白（ＨｂＡ１ｃ）水平的关系．结果表明：ＮＩＤＤＭ患者红细胞膜微粘度明显高于同年龄正常对照组，提示其红细胞膜流动性降低。并且患者膜微粘度与ＦＢＧ浓度和ＨｂＡ崐１ｃ水平呈明显正相关，而与ＦＰＩ浓度呈明显负相关，上述结果说明ＮＩＤＤＭ患者红细胞膜流动性改变与病情控制有关。
Erythrocyte membrane fluidity and its relationship with fasting plasma insulin(EPI),fasting blood glucose(FBG)and glycosylated haemoglobin(HbA1c)levels were studied in 65 noninsulin-dependent diabetes mellitus(NIDDM)The results showed that NIDDM patients had incrased erythrocyte membranemicroviscosity2.543±0.294 in 65 NIDDM vs 2.250±0.226 poise in 29 controls,P<0.01)as compared with the age-matchedcontrol group.This result suggested a decreased erythrocyte membrane fluidity in NIDDM patients.Themicroviscosity of erythrocyte membrane from diatebic subjects was significantlycorrelated FBG(r=0.227,P<0.05)and HbA1c levels(r=0.399,P<0.01),inversely correlated with FPI(r=-0.233,P<0.05).These results indicated that erythrocyte membrane fluidity was closely related with diabetic control inNIDDM.
出处
《重庆医科大学学报》
CAS
CSCD
1997年第2期100-101,共2页
Journal of Chongqing Medical University
关键词
NIDDM
膜流动性
胰岛素
糖尿病
糖化血红蛋白
Noninsulin-dependent diabetes(NIDDM)
erythrocyte membrane fluidity
Membrane microviscosity
Fasting plasma insulin(FPI)
Glycosylated haemoglobin(hbA1c)
