摘要
目的探讨复方丹参滴丸(DSP)对高原低氧多器官组织病理改变的影响。方法将平原大鼠运入高原(海拔5000m),随机分为DSP干预组(7只)和对照组(7只),实验20天后全部处死,取出心、肝、脾、肺、肾、脑组织用光电镜观察。结果与对照组比较,DSP干预组大鼠的组织病理改变明显轻微。结论DSP能预防、改善细胞的低氧性水肿、变性、坏死等损伤,是高原自然环境条件下比较特异的低氧性器官组织损伤的保护剂。
Objective To investigate the intervention of salviae dropping pill （DSP） Compound on tissue pathologic injury of muhiorgan caused by hypoxia. Methods 200g-250g weight of 14 rats in plain were moved to 5000m high altitude, they were randomly divided into medication group（ n = 7 ）and control group （n = 7） and put them to die after 20 days at plateau. Their tissues of heart, live, spleen, lungs, kidneys and brain tissue were observed under light and transmission electron microscope. Results Tissue pathologic change of medication group was very light Compare with control group. The damage of organ tissue was more serious its improvement was more obvi- ous treated with DSP. Conclusion DSP can prevent hypoxia damage of cellular swelling, degeneration, necrosis etc. DSP is a good compound for treating tissue and cell damage caused by hypoxia.
出处
《青海医学院学报》
CAS
2007年第3期194-197,共4页
Journal of Qinghai Medical College
基金
青海省医药卫生科研指导性计划课题(NO:y-205-2003-68)
关键词
复方丹参滴丸
大鼠
低氧
干预
Salviae dropping pill compound High altitude Hypoxia intervention
