摘要
粘附分子通过介导细胞间相互作用发挥其在发育、再生和突触修饰等方面的重要作用.神经细胞粘附分子CHL1(close homologue of L1)是近年发现的粘附分子,属于粘附分子免疫球蛋白超家族,集中表达于神经系统,通过亲异性作用(heterophilic interaction)介导细胞与细胞、细胞与胞外基质的相互作用,进而参与神经系统的发育、轴突的生长、迁移及导向等过程.
Cell adhesion molecules （CAMs） play important roles in specifying cell-cell interactions during development, regeneration, and modification of synaptic activity. The close homolog of L1 （CHL1）, a recently identified member of the immunoglobulin superfamily of cell adhesion molecules, is localizably expressed in the nervous system. CHL1 interacts with like molecules （homophilic interaction） and non-like molecules （heterophilic interaction） on neighboring cells or the extracellular matrix to regulate axon outgrowth and fasciculation, neuronal migration and survival, synaptic plasticity and regeneration after trauma.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2007年第9期925-928,共4页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目(30670792).~~
