摘要
通过胆总管结扎法，制造犬肝硬变门脉高压模型，并直接测定丹参注射液对肝硬变犬门脉压力及胃粘膜血流（GMBF）的影响。结果表明，静注丹参注射液后，肝硬变犬的门脉压力（PpV）、嵌塞肝静脉压（WHVP）、肝静脉压力梯度（HVPG）显著下降（P＜0．01），平均动脉压（MAP）、心率（HR）无显著变化（P＞0．05）。给药后10min，肝硬变及正常犬的GMBF显著增加（P＜0．05）．用药后30min达最高值（P＜0．01），60min后GMBF稍有下降．但与用药前比较仍有显著差异（P＜0．05）。说明丹参在降低肝硬变犬门脉压力的同时改善GMBF，对血压、心率无显著影响。为副作用小，兼具降低门脉压力与保护胃粘膜作用的药物。
The models of hepato-cirrhotic dogs was made by chronic bile duct ligation,theportal venous pressure and gastric mucosal blood flow (GMBF) in cirrhotic dogs affected by usingRadix Salviae Miltiorrhizae (RSM) were mesured directly. The results showed that, after intravenous administration of RSM,the portal venous pressure (Ppv),wedge hepatic venous pressure(WHVP),hepatic venous pressure gradient (HVPG) of cirrhotic dogs were sigficantly decreasedP ＜0.01 ),but mean arterial pressure (MAP) and heart rate (HR) unchanged (P ＞0. 05 ). Tenminutes after intravenous administration of RSM,the GMBF in cirrhotic and normal dogs were sigficantly increased (P ＜0. 05),thirty minutes later,the GMBF reached the peak (P ＜0. 01 ) sixtyminutes later, the GMBF decreased, but it was still higher than that using drugs before (P ＜0. 05 ). The results demonstrated, after intravenous administration of RSM, when Ppv was depressed,GMBF was improved,the MAP and HR unchanged. RSM is a effective drugs that both indepressing Ppv and protecting gastric mucus with few side effects.
关键词
丹参
中药肝硬变
门脉压
胃粘膜血流
药理学
Radix Salviae Miltiorrhizae ,portal hyperension ,gastric mucosal blood flow ,hepato-cirrhosis
