摘要
用大鼠研究条件化低强度声刺激对高强度声刺激的保护作用。动物暴露于中心频率为４ｋＨｚ的倍频程窄带噪声，强度５５～９５ｄＢＳＰＬ１０小时，然后再暴露动物于噪声１０５ｄＢＳＰＬ１３小时，暴露前、暴露后即刻及３周检测ＡＢＲ阈值。先条件化噪声暴露组动物可以减轻ＴＴＳ和ＰＴＳ，结果提示在大鼠内耳有“坚韧化”现象，这种现象可以用本实验较短的条件化噪声诱发出。对条件化噪声暴露防护强声暴露的机理进行了讨论。
Effect of low level acoustic stimulation,or 'conditioning' on the sensitivity to subsequent intensity noise exposure were studied in rats.The animals was conditioned with octave bandpass noise,centered at 4 kHz,of 55 to 95 dB SPL for ten hours before the traumatic exposure to the noise of the same nature but at 105 dB SPL and for 13 hours.Auditory brain stem response thresholds were measured before,immediately after and three weeks after the exposures.The results show that acoustic conditioning decreased both temporary and permanent threshold shift induced by the traumatic exposures,indicating there is a toughening of the rat's cochlea by the low level stimulation used in this study.Possible mechanism of the phenomenon was discussed.
出处
《听力学及言语疾病杂志》
CAS
CSCD
1997年第1期3-5,共3页
Journal of Audiology and Speech Pathology
