摘要
目的：从中西医病、证结合及治疗探讨老年脑血管病患者的Ｔ淋巴细胞亚群的变化。方法：采用荧光免疫法检测１２９例老年脑血管病患者Ｔ淋巴细胞亚群。结果：脑梗塞和脑出血患者的Ｔ淋巴细胞亚群均表现为ＣＤ＋３降低、ＣＤ＋８升高、ＣＤ＋４／ＣＤ＋８降低，与正常组相比，有显著差异（Ｐ＜００１），而脑梗塞组的ＣＤ＋３降低比脑出血更明显（Ｐ＜００５）。并且，脑梗塞组虚实夹杂证以ＣＤ＋３、ＣＤ＋４降低为主，脑出血组以ＣＤ＋８升高、ＣＤ＋４／ＣＤ＋８降低为主（Ｐ＜００１，Ｐ＜００５）。通过脑梗通治疗脑梗塞前后Ｔ淋巴细胞亚群变化并与川芎嗪对照，发现脑梗通对降低两证型组的ＣＤ＋８、升高ＣＤ＋４／ＣＤ＋８比值及升高虚实夹杂证组的ＣＤ＋３有显著意义（Ｐ＜００５）。结论：免疫功能低下及调节失衡对脑血管病的发生、发展及预后有重要影响，脑血管发病后又加重了免疫调节失衡。中医辨证分型上虽无本质区别，但在免疫机制上存在差异。脑梗通对脑梗塞不同证型的免疫异常具有调节作用，取得了更好的疗效。
Objective:To study the change of periphery T lymphocyte subpopulation in 129 cases of NaoGengTong and western medicine treated senile cardiovascular disease with differential diagnosis by traditional Chinese medicine(TCM) method.Methods: Measuring the change of T lymphocyte subpopualtion in 129 cases of senile cerebrovascular disease by indirect immunoflurorescent method.Results:Cases with both cerebral infarction(CI) and intracerebral hemorrhage(ICH) showed lower CD + 3,higher CD + 8,lower CD + 3/CD + 8 as compared with normal values.The difference was significant( P <0 01).And the lower of CD + 3 of CI was more marked than that of ICH( P <0 05).Those cases with syndrome of deficiency complicated with excessiveness in CI group had mainly lower CD + 3 and CD + 4,while cases with excessiveness syndrome in ICH group had mainly higher CD + 8 and CD + 4/CD + 8( P <0 05, P <0 01).The change of T lymphocyte subpopulation was measured at the beginning and the end of the NaoGengTong treatment,and was compared that with Injectio Ligustrazini Hydrochloridi treatment.It was found that in NaoGengTong treated cases,there were significant decrease of CD + 8,and increase of CD + 3/CD + 8 in cases with both kinds of syndromes;and increase of CD + 3 in cases with deficiency complicated excessiveness syndrome.Conclusion:Decreased immunity and disorder of immunity regulation have important impact on the onset,development and prognosis of cerebrovascular disease.And cerebrovascular disease,in turn,aggravate the disorder of immunity regulation.There is difference in immunity of CI and ICH,yet both of them could be diagnosed as same syndrome in TCM terminology. NaoGengTong could restore to normal of the abnormal immunity of different syndromes of TCM of CI with good therapeutic effects.
出处
《中日友好医院学报》
1997年第1期67-70,共4页
Journal of China-Japan Friendship Hospital
关键词
脑动脉疾病
老年人
免疫
T淋巴细胞亚群
cerebral artery disease
aged
traditional Chinese medicine
immunity
T lymphocyte subpopulation
