摘要
目的探讨米索前列醇预防产后出血的有效性和安全性。方法分析阴道分娩90例存在产后出血高危因素且无前列醇使用禁忌证的产妇，随机分为两组。观察组于分娩后直肠给予米索前列醇400gg，对照组于分娩后立即静注催产素20^U。比较两组第三产程出血量，产后出血及不良反应。结果试验组第三产程产后2h及24h出血量分别为（137．5±11．9）ml、（183．2±14．4）ml，对照组产后2h及24h出血量分别为（206．2±16．1）ml、（244．5±19．6）ml；分别比较有显著性差异（P〈0,01）。试验组第三产程时间为（6±4．9）min，对照组第三产程时间为（15±8．2）min，有显著性差异，P〈0．01。结论米索前列醇直肠用药能较好的预防产后出血，且安全及用药方便。
Objective To discuss the effect and safety of misoprotol on prevention of postpartum bleeding after vaginal delivery. Methods Ninety pregnancy who have high risk of bleeding and have no prostaglandin were randomized into two groups：observe group（400pg misoprostol was set into rectum） and control group （20^U oxytocin was injected immediately after vaginal delivery） .The amout of bleeding, the rate of third stage of labor, postpartum bleeding and the side effects of drugs between the two groups were compared. Results The mean amout of bleeding with in 2 hours and 24 hours after vaginal delivery in misoprotol group was （137.5±11.9）ml, （183.2 ± 14,4） ml; while in oxytocin group was （206.2± 16.1）ml,（244.5± 19.6）ml; The difference was sinificant （P〈0.01）. The time of third stage of labor in misoprotol group was （6±4.9）minutes; while in oxytocin group was （15±8.2） minutes, The difference was sinificant（P〈0.01）, Conclusion Misoprostol set into rectum is more effective in prevention of postpartum bleeding than oxytocin.
出处
《中华临床医学杂志》
2007年第8期10-11,共2页
Chinese Journal of Clinical Practical Medicine
关键词
米索前列醇
产后出血
预防
Misoprotol Postpartum bleeding Prevention
