摘要
目的为研究表皮生长因子受体（ＥＧＦＲ）、转化生长因子α（ＴＧＦ┐α）与卵巢癌发生、发展的关系。方法用原位杂交法研究了ＥＧＦＲ、ＴＧＦ┐α、ＥＧＦｍＲＮＡ在７２例卵巢肿瘤及正常卵巢组织中的表达。结果ＴＧＦ┐α在卵巢癌中的检出率为５７．８９％。在良性肿瘤、交界性肿瘤和正常卵巢组织中的检出率分别为２０．００％、３３．３３％和１６．６７％。各组与卵巢癌组间均有显著差异（Ｐ＜０．０５）。ＥＧＦＲ在上述组中的表达率分别为６５．７９％、２０．００％、３３．３３％和２５．００％，后三者与卵巢癌组间有显著差异（Ｐ＜０．０５）。ＴＧＦ┐α和ＥＧＦＲ在各期卵巢癌中的表达率分别为：Ｉ期１２．５％和５０．００％、Ⅱａ、ｂ期；７０．５９％、５８．８２％、Ⅱｃ～Ⅳ期：６９．２３％和４６．１５％，ＥＧＦ在上述各类组织中极少表达。结论ＴＧＦ┐α和ＥＧＦＲ在卵巢肿瘤中有高水平的表达，且临床分期越晚，恶性程度越高，表达率越高，提示ＴＧＦ┐α／ＥＧＦＲ自分泌系统在卵巢癌的发生发展起着重要的作用，而ＥＧＦ／ＥＧＦＲ这一系统可能不发挥作用。
Objective:To study the relationship between TGF α、EGFR and EGF and the development and occurrence of ovarian cancer. Methods:In situ hybridization was used to investigate the expression of EGFR,TGF α,EGF in 72 cases of ovarian neoplasm. Results:The positive rate of TGF α mRNA in ovarian cancer,benign tumor,borderline tumor and normal ovarian tissue was 57 89%,20 00%,33 3%,16 67% respectively. There was significant difference between ovarian cancer group and other groups( P <0 05).The expression rate of EGFR mRNA in above groups was 65 79%,20 00%,33 33% and 25 0% respectively. There was significant difference between ovarian cancer group and other groups ( P <0 05).The expression rate of TGF α and EGFR were that phase I:12 50% and 50 00% phase Ⅱ a.b:70 59%,phase Ⅱ c～Ⅳ: 69 23% and 46 15%. Very low positive rate of EGF was detected. Conclusions:TGF α and EGFR autocrine mechanism played an important role in the occurrence and development of ovarian cancer. But EGF/EGFR did not.
出处
《肿瘤》
CAS
CSCD
北大核心
1997年第3期137-139,共3页
Tumor
关键词
卵巢肿瘤
表皮生长因子
转化生长因子
Ovarian neoplasm Epidermal growth factor Epidermal growth factor recepter Transforming growth factor α In situ hybridization.
