摘要
目的:研究芍药甘草复方大鼠给药后血中移行组分归属。方法:建立芍药甘草复方大鼠给药后血中移行组分HPLC分析方法;分析比较芍药甘草复方、单味药以及各组分给药后所得血浆样品,确认芍药甘草复方大鼠血中移行组分归属。结果:在此色谱条件下,检测出18个入血移行成分,其中13个为复方直接入血物质,3个为复方的代谢产物。结论:此方法简便、准确、稳定,适于芍药甘草血中移行组分分析。血中移行组分的确认及归属是进一步探索复方效应物质的基础。
Objective： To study the adscription of plasma effective constituents of rat after oral administration of Paeonia lacliflora and Glycyrrhiza uralensis compound. Method： Based on the established HPLC analytical method of plasma effective constituents, analysis and comparison were carried out among HPLC profiles of plasma samples obtained after oral administration of different ingredient preparations such as P. lacliflora and G. uralensis compound, single ingredient and all the preparations. The adscription of plasma effective compounds were identified. Result： Eighteen compounds were detected under this method, three of which are metabolites and thirteen are original forum of compounds contained in P. lacliflora and G. uralensis compound. Conclusion： This method is simple, accurate and stable, it could be used to analyze plasma effective constituents of P. lacliflora and G. uralensis compound. Affirmation of plasma effective compounds is the basis of to explore active compounds of P. lacliflora and G. uralensis compound.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第17期1789-1791,共3页
China Journal of Chinese Materia Medica
基金
上海市科委基础研究专项(04DZ19841)
关键词
芍药甘草
移行组分
高效液相色谱法
Paeonia lacliflora and Glycyrrhiza uralensis
effective constituents
HPLC
