摘要
目的探讨急性低血压通过兴奋前庭神经核调节血压的中枢机制中,影响孤束核(NTS)功能活动的神经化学机制。方法利用微量透析法和高效液相色谱-电化学检测法,测定失血诱发急性低血压时正常和破坏一侧前庭器官大鼠孤束核细胞外液中谷氨酸(Glu)和牛磺酸(Tau)含量的变化。结果诱发急性低血压在正常大鼠NTS细胞外液中Glu和Tau的含量均明显增加(P<0.05),另外药物破坏一侧前庭器官(UL)后再诱发急性低血压时损伤侧NTS细胞外液中Glu和Tau含量仍然明显增加,与正常组相比较无显著性差异。结论在急性低血压诱发前庭神经核兴奋调节血压的中枢机制中,通过释放谷氨酸和牛黄酸影响NTS的活动,除此之外可能还有其他机制的参与。
[Objective] To illuminate the effect of NTS function neurochemistry mechanism in acute hypotension through exciting vestibular nucleus in the central regulation of cardiovascular. [Methods] Vivo microdialysis technique and high-performance liquid chromatography （HPLC） were used to measure extracellular fluid levels of glutamate （Glu） and taurine （Tau） in the nucleus solitary tract （NTS） by acute hemorrhage in the anesthetized rats. [Resuits] The content of Glu and Tau was increased （P 〈0.05） in the NTS on the normal and unilateral labyrinthectomy rats. However, these changes were not significant differences between two groups. [Conclusions] The results suggest that Glu and Tau effect the acitivity of the NTS, and there are the other mechanisms participate in the course of acute hypotension inducing vestibular nucleus excitation through NTS regulation of cardiovascular.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第16期1970-1973,共4页
China Journal of Modern Medicine
关键词
孤束核
谷氨酸
牛磺酸
急性低血压
前庭神经核
nucleus solitary tract
glutamate
taurine
acute hypotension
vestibular nucleus
