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IL-6和β2微球蛋白检测在多发性骨髓瘤中的临床意义 被引量:3

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摘要 目的:探讨IL-6和β2微球蛋白(β2-MG)在多发性骨髓瘤(MM)患者中治疗及预后中的应用价值。方法:对47例MM患者和30例正常对照应用ELISA法测定其血清IL-6含量,应用放射免疫法检测其血清β2-MG含量,分析不同临床分期及治疗前后的IL-6和β2-MG变化。结果:MM组IL-6和β2-MG水平明显高于正常对照组(P〈0.05);Ⅱ期和Ⅲ期MM患者IL-6和β2-MG水平高于I期(P〈0.05),Ⅱ期和Ⅲ期间IL-6和β2-MG水平差异无统计学意义(P〉0.05);MM患者治疗有效组(CR或PR组)IL-6和β2-MG水平在治疗前后有明显下降(P〈0.05),而治疗无效组(NR组)治疗前后IL-6和β2-MG水平无明显差异(P〉0.05)。结论:IL-6和β2-MG对MM临床分期、疗效及预后判断有重要临床意义。
出处 《国际检验医学杂志》 CAS 2007年第8期746-747,共2页 International Journal of Laboratory Medicine
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参考文献6

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