期刊文献+

2型糖尿病伴非酒精性脂肪肝临床分析 被引量:9

暂未订购
导出
摘要 非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD,以下简称脂肪肝)是一种病变主体在肝叶,以肝细胞脂肪变性和贮积为病理特征但无过量饮酒史的临床综合征。2型糖尿病并发脂肪肝发生率高达46%,近来许多研究表明脂肪肝与代谢综合征密切相关。本文旨在探讨2型糖尿病合并脂肪肝与肥胖、胰岛素抵抗(IR)、血脂水平等之间的关系,为临床防治提供依据。
作者 相莉 李金荣
出处 《天津医药》 CAS 北大核心 2007年第8期609-610,共2页 Tianjin Medical Journal
  • 相关文献

参考文献5

二级参考文献21

  • 1McCullough,AJ.Update on non-alcoholic fatty liver disease.J Clin Gastroenterol,2002,34:225- 262.
  • 2Bernal-Reyes R,Saenz-Labra A,Bernaydo-Escudero R.Prevalence of non-alcoholic steatohepatitis.Comparative study with diabetic patients. Review Gastroenterol Mexico,2000, 65: 58-62.
  • 3Luyckx FH,Lefebvre PJ,Scheen AJ,et al. Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. Diabetes Meteb, 2000, 26:98-106.
  • 4Kaplan LM. Leptin,obesity,and liver disease.Gastroenterology, 1998, 115:997-1001.
  • 5Montague CT, Farooqi IS,Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature,1997,387:903-908.
  • 6Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes,2002,51:1437-1442.
  • 7Higa M, Zhou YT, Ravazzola M, et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci USA, 1999,96:11513-11518.
  • 8Unger RH, Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J, 2001,15:312-321.
  • 9Okuya S, Tanabe K, Tanizawa Y,et al. Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis. Endocrinology,2001,142: 4827-4830.
  • 10Lee Y, Wang MY, Kakuma T, et al. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem, 2001,276: 5629-5635.

共引文献1522

同被引文献53

引证文献9

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部