摘要
低剂量的溶栓酶用于大鼠能引起纤维蛋白原（Ｆｂｇ）平均下降４５％，凝血酶时间（ＴＴ）由１１．１３秒延长到２２．６３秒（Ｐ＜０．０１），而凝血酶原时间（ＰＴ）及白陶土部分凝血活酶时间（ＫＰＴＴ）无显著性变化（Ｐ＞０．０５）。但高剂量的溶栓酶除能明显降低Ｆｂｇ和延长ＴＴ外，而且可使ＰＴ由１６．８２秒延长到７３．４４秒及ＫＰＴＴ由４６．６３秒延长到１２４．１３秒，并能使Ⅱ、Ⅷ因子降解。
The earthworm fibrinolytic enzyme injected in rats at a lower dosage (750μ/ml) resulted in decreased fibrinogen (Fbg) by av. 44% and prolonged thrombin time (TT) from 11.15 sec. to 22.63 sec. (P<0.01), while no obvious change were observed on the prothrombin time (PT) and kaolin partial thromboplastin time (KPTT) (Table 1). At a higher dosage (1500μ/ml), however, marked decrease of Fbg and marked prolongation of TT were observed. In addition, not only PT and KPTT both markedly prolonged, but also resulted in the degradation of factors I and VIII and hence strengthed the antithrombotic effect.
关键词
蚯蚓溶栓酶
凝血
纤溶
药理
Earthworm fibrinoltic enzyme
Coagulation
Fibrinolysis
