地塞米松对全麻下原发性肺癌病人术中血清脂质过氧化物和皮质醇、胰岛素的影响

Effect of Dexamethasone on serum lipoperoxides and cortical,insulin in patients with primary lung cancer during operation under general anesthesia

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摘要为探讨原发性肺癌病人麻醉术中血清脂质过氧化物（ＬＰＯ）含量变化，我们在麻醉诱导前给予地塞米松，采用氯胺酮—安氟醚静吸复合麻醉测定了血清ＬＰＯ含量，并且观察了皮质醇和胰岛素的变化。结果表明：ＬＰＯ术终与健康者和麻醉前比较显著降低（Ｐ＜０．０５），而血清皮质醇和胰岛素在插管后和术终与麻醉前比较显著增高（Ｐ＜０．０１）。认为地塞米松具有显著减缓脂质过氧化反应，降低ＬＰＯ含量的作用。 The changes of serum lipoperoxides (LPO) and cortical,insulin in patients with primary lung cancer were observed when the patients were given Dexamethasone 0.4 mg/kg before anesthesia induction under Ketamine Enflurane intravenous inhalation anesthesia.The results showed that the contents of LPO of the patients at the end of operation were significantly lower than those before anesthesia and in the healthy ( P <0 05),but the levels of serum cortical and insulin after intubation and at the end of operation were significantly higher than those before anesthesia ( P <0 01).Furthermore,it indicated that Dexamethasone decreased lipid peroxidation reaction and reduced the function of the contents of LPO in the patients.

作者马占文王宏宇郭宝富卢文杰王天元

机构地区第三临床学院麻醉科

出处《白求恩医科大学学报》 CSCD 1997年第2期176-178,共3页 Journal of Norman Bethune University of Medical Science

关键词全身麻醉肺癌皮质醇胰岛素地塞米松 LPO General anesthesia Lung cancer Lipoperoxides Cortical Insulin

分类号 R614.2 [医药卫生—麻醉学] R734.205 [医药卫生—肿瘤]