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色氨酸羟化酶基因多态性与精神分裂症的关联研究 被引量：7

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摘要 目的探讨中国汉族人群色氨酸羟化酶（TPH）基因A218C多态性与精神分裂症的关系。方法选取符合美国精神障碍诊断与统计手册第4版（DSM-IV）精神分裂症诊断标准的患者212例和正常对照168名,应用聚合酶链式反应（PCR）扩增及限制性片段长度多态性（RFLP）技术检测TPH基因A218C多态性,比较两组基因型和等位基因频率。结果TPH基因的A218C多态性基因型和等位基因频数在患者组与对照组间的分布差异无统计学意义（P〉0.05）。②女性患者等位基因A频率显著高于女性对照组（χ2=4.905,P=0.027,OR=1.637,95%CI：1.057~2.536）。③早发型与晚发型分裂症间基因型和等位基因频率的差异无统计学意义（P〉0.05）。④患者组家族史阴性和阳性亚组间的A218C多态性的基因型和等位基因频率的差异无统计学意义（P〉0.05）。结论TPH基因A218C多态性等位基因A可能是女性精神分裂症的危险因子。
作者 王从辉 石玉中 吕路线 左津淮 陈红昊
机构地区 新乡医学院第二附属医院 天津市安定医院
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2007年第8期478-479,共2页 Chinese Journal of Nervous and Mental Diseases
关键词 精神分裂症 色氨酸羟化酶 基因 多态性 关联分析
分类号 R749.3 [医药卫生—神经病学与精神病学] R394.3 [医药卫生—医学遗传学]
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参考文献8

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同被引文献37

  • 1张玉琦,袁国桢,李桂林,刘朝军,刘庆海,王爱荣,史桂芝,王宝恒,成义仁,张明廉,李克.TPH2基因rs7305115单核苷酸多态性与抑郁症自杀未遂的关联研究[J].中国神经精神疾病杂志,2007,33(2):103-105. 被引量：15
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  • 10Miguel EC,Leckman JF,Rauch S,et al. Obsessive- compulsive disordex phenotypes: implications for genetic studies. Mol Psychiatry, 2005, 10(3) : 258 -275.

引证文献7

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中国神经精神疾病杂志
2007年 第8期

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