摘要
根据Lauren分型,胃癌分为肠型和弥漫型胃癌两种.肠型胃癌经历了正常胃黏膜、肠上皮化生到异型增生再到肠型胃癌的多步骤、多阶段逐渐发展的过程.肠道特异性转录因子(caudal-related homeobox transcription factor 2,CDX2),对肠黏膜上皮的发育及保持其形态起着重要作用.正常情况下其产物特异的表达于小肠和结肠上皮中.迄今的研究发现,CDX2基因的异常表达与胃黏膜肠上皮化生和肠型胃癌的发生密切相关.
Gastric carcinoma can be divided into two types by the Lauren classification： intestinal and diffuse-type carcinoma. Intestinal-type carcinoma is thought to develop from normal mucosa, intestinal metasplasia and dysplasia, ultimately leading to gastric cancer. Caudal-related homeo- box transcription factor 2 （CDX2）, an intestinal- specific transcription factor, is a member of the caudal- related homeobox gene family and plays an important role in the development and differentiation of intestinal epithelium, and in the maintenance of intestinal phenotype. In normal adults, CDX2 is expressed in mucosa from the duodenum to the distal colon. Recent studies have found that aberrant expression of CDX2 plays a crucial role in intestinal metaplasia formation and intestinal carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第18期2037-2041,共5页
World Chinese Journal of Digestology
关键词
果蝇相关同源异型框转录因子2
异型增生
肠化生
胃癌
Caudal-related homeobox transcription factor 2
Dysplasia
Intestinal metaplasia
Gastric carcinoma
