期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肾移植术后监测CsA血药浓度C_2和C_0对指导CsA合理应用的临床价值 被引量：4

Clinical value of supervising rational application of CsA by monitoring CsA concentration C2 and C0 in kidney transplant recipients
暂未订购
导出
摘要 目的:比较监测肾移植术后服用环孢素A(CsA)的血药浓度峰值(C2)和谷值浓度(C0)对判定CsA抗排斥疗效及毒副作用的临床价值。方法:采用免疫荧光偏振TDX法监测365例肾移植受者CsA浓度,其中212例监测CsA峰值浓度(C2组),153例监测CsA谷值浓度(C0组)。分析两组CsA浓度测定值与患者移植肾功能、急性排斥反应、药物性肝肾中毒以及肺感染相关临床资料的关系。结果:急性排斥反应的发生率C2组(19.8%)明显低于C0组(26.1%),两组比较差异有显著性(P<0.05);药物性肝、肾中毒及肺感染的发生率C2组分别为18.3%、10.5%和13.7%,C0组分别为20.3%、9.9%和14.2%,两组比较差异均无显著性(P>0.05)。结论:CsA血药浓度C2和C0监测都是肾移植术后药物调控的有效指标,C2在监控急性排斥方面意义更大。
作者 周洪澜 李路江 王金国 傅耀文 王伟刚 薛立娟 张文岚
机构地区 吉林大学第一医院器官移植中心
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2007年第4期757-759,共3页 Journal of Jilin University：Medicine Edition
基金 吉林省科技厅基金资助课题(20030537-1) 吉林大学青年教师基金资助课题(2003QN043)
关键词 肾移植 环孢素 药物监测
分类号 R979.5 [医药卫生—药品] R617 [医药卫生—外科学]
  • 相关文献

参考文献11

  • 1Belitsky P,Levy GA,Johnston A.Neoral absorption profiling:an evolution in effectiveness[J].Transplant Proc,2000,32 (Suppl 3A):45-52.
  • 2Johnston A,David OJ,Cooney GF.Pharmacokinetic validation of Neoral absorption profiling[J].Transplant Proc,2000,32 (Suppl 3A):53-56.
  • 3Dumont RJ,Ensom MH.Methods for clinical mornitoring of cyclosporine in transplant patients[J].Clin Pharmacokinet,2000,38 (5):427-447.
  • 4Jensen SA,Dalhoff KP.Therapeutic monitoring by blood concentrations with the focus on cyclosporine A[J].Ugeskr Laeger,2001,163 (14):2009.
  • 5Morris RG,Russ GR,Cervelli MJ,et al.Comparison of trough,2-hour,and limited AUC blood sampling for monitoring cyclosporine (Neoral) at day 7 post-renal transplantation and incidence of rejection in the first month[J].Ther Drug Monit,2002,24 (4):479-486.
  • 6Oellerich M,Armstrong VW.Two-hour cyclosporing concertration determination:an appropriate tool to monitor neural therapy[J].Ther Drug Monit,2002,24 (1):40-46.
  • 7石炳毅.环孢素A的药代动力学特性与C2监测的优越性[J].中华泌尿外科杂志,2003,24(3):210-212. 被引量：7
  • 8闻质红,赵峻,张莉蓉,宋东奎.肾移植术后环孢素A血药浓度C_2监测[J].郑州大学学报（医学版）,2006,41(6):1162-1164. 被引量：4
  • 9Cole E,Maham N,Cardella C,et al.Clinical benefits of neural C2 monitoring in the long-term management of renal transplant recipients[J].Transplantation,2003,75 (12):2086-2090.
  • 10谭建明,唐孝达.国人肾移植术后微乳化环孢素血药浓度C2监测的临床意义[J].中华泌尿外科杂志,2003,24(3):172-174. 被引量：9

二级参考文献19

  • 1Mueller EA,Kovarik JM,van Bree JB,et al.Pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine in renal allograft recipients-a concentration-controlled comparison with the commercial formulation[J].Transplantation,1994,57(8):1178-1182.
  • 2Kovarik JM,Mueller EA,van Bree JB,et al.Cyclosporine pharmacokinetics and variability from a microemulsion formulation-a multicenter investigation in kidney transplant patients[J].Transplantation,1994,58(6):658-663.
  • 3Taesch S,Niese D.Safety and tolerability of a new oral formulation of cyclosporin A,sandimmun neoral,in renal transplant patients[J].Transpl Int,1994,7 (Suppl 1):S263-S266.
  • 4Wahlberg J,Wilczek HE,Fauchald P,et al.Consistent absorption of cyclosporine from a microemulsion formulation assessed in stable renal transplant recipients over a one-year study period[J].Transplantation,1995,60(7):648-652.
  • 5Cantarovich M,Besner JG,Barkun JS,et al.Two-hour cyclosporine level determination is the appropriate tool to monitor Neoral therapy[J].Clin Transplant,1998,12(3):243-249.
  • 6Cole E,Cattran D,OGrady C.Conversion from C0 to C2 monitoring may permit optimization of longterm neoral exposure in stable renal transplant recipients:a transplant odyssey,20-23 2001,Istanbul.Abstract 1356.
  • 7Cole E,Walele A,Cattran DL,et al.Use Of C2 monitoring to optimise cyclosporine microemulsion dosing in de novo renal transplant recipients:a Safety Analysis Joint meeting of the AST/ASTS,2001,Chicago.Abstract 220.
  • 8Canadian Neoral Renal Transplantation Study Group.Absorption profiling of cyclosporine microemulsion (Neoral) during the first 2 weeks after renal transplantation[J].Transplantation,2001,72(6):1024-1032.
  • 9Pfeffer P,Stefoni S,Carreno C,et al.Monitoring of 2-hour Neoral absorption in renal transplantion shows low incidence of acute rejection in the early post-graft period:interim results of the MO2ART study.2002,Washington D.C.Abstract 1037.
  • 10Cole E,Maham N,Cardella C,et al.Clinical benefits of neural C2 monitoring in the long-term management of renal transplant recipients[J].Transplantation,2003,75(12):2086-2090.

共引文献20

同被引文献47

引证文献4

二级引证文献12

吉林大学学报（医学版）
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部