摘要
目的:评价神经节苷脂在促进吉兰-巴雷患者恢复方面上的临床疗效及肌电图变化。方法:将符合入选标准的36例患者随机分为2组,分别采用神经节苷脂和普通B族维生素治疗。治疗前后对两组患者定期进行MRC、Hughes评分以及肌电图检查,测定运动神经传导速度及F波平均潜伏期。结果:两组MRC、Hughes评分与治疗前相比均有显著或极显著差异(P<0.05-0.01),半年后两组MRC、Hughes评分比较有显著差异(P<0.05),半年后两组运动神经传导速度、F波潜伏期比较有显著差异(P<0.05),两组无明显不良反应。结论:神经节苷脂是促进吉兰-巴雷患者恢复的有效药物,无论是临床评分还是肌电图改善均优于普通B族维生素。
Objective： To assess the clinical effects and the changes in EMG of monosialote trahexosyl ganglioside for improving the recovery of Guillain-Barre syndrome. Methods： 36 patients who conformed with the standard were randomly divided into two groups and treated with monosialote trahexosyl ganglioside or B-group vitamin, respectively. The scores MRC and Hughes were used to evaluate the neurological deficits and EMG was used to determine the MCV and Flatency of the two groups regularly before and after treatment,. Results： There was a significant or more significant difference in the scores before and after treatment（ P〈0. 05 - 0. 01） 3 there was a significant difference in the scores and in the MCV and F-latency between the two groups after half one year, no distinct adverse reaction happened in the two groups. Conclusion： The monosialote trahexosyl ganglioside is a effective medicine for improving the recovery of Guillain- Barre syndrome,and it is superior to the B-group vitamin no matter in the scores or in EMG.
出处
《脑与神经疾病杂志》
2007年第4期283-285,共3页
Journal of Brain and Nervous Diseases
关键词
神经节苷脂
B族维生素
肌电图
吉兰-巴雷综合征
Monosialote trahexosyl ganglioside B-group vitamin EMG Guillain-Barre syndrome
