摘要
目的:探讨血管性痴呆(vascular dementia,VD)小鼠海马突触后致密物95(postsynaptic density95,PSD-95)表达的变化。方法:双侧颈总动脉线结,反复缺血-再灌注法制备小鼠VD模型,跳台试验观测其行为学改变,免疫组织化学方法观察海马齿状回PSD-95的表达。结果:模型组小鼠学习、记忆成绩下降(P<0.05),其海马齿状回(dentategyrus,DG)PSD-95免疫阳性产物较对照组明显减少(P<0.05)。结论:VD模型小鼠学习记忆能力下降可能与海马PSD-95的表达减少有关。
Objective： To explore the changes of the expression of postsynaptic density 95 （PSD-95） in hippocampus of mice with vascular dementia （VD）. Methods： The mice were subjected for ischemia reperfusion repeatly on bilateral common carotid arteries by knots to establish the VD models. The changes of behavior were observed through the step-down avoidance test and the expression of PSD-95 was observed by immunohistochemical method. Results： The abilities of the learning and memory of VD mice was impaired. The immunoreactivity of PSD-95 in hippocampal dentate gyrus（DG） decreased （P〈0.05）. Conclusion： The impairment of the abilities of learning and memory of VD mice might be related with the change of PSD-95 in hippocampus.
出处
《脑与神经疾病杂志》
2007年第4期258-259,265,共3页
Journal of Brain and Nervous Diseases
关键词
血管性痴呆
学习记忆
突触后致密物95
Vascular dementia Learning and Memory Postsynaptic density 95
