4[1]Guenther B. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.Diabetes,1997,46:3～10
5[2]Ana TMGS,Guenther B,Maria ERS,et al. Overnight lowering of free fatty acid with Acipimox improves insulin resistance and glucose toler ance in obese diabetic and nondiabetic subjects [J].Diabetes,1999,48:1836～1841
6[3]Margaret E,Griffin,Melisssa J,et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade .[J]Diabetes,1999,48:1270～1274
7[4]Anai M,Funaki M,Ogihara T,et al. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in zucker fatty rats[J].Diabetes,1998,47:13～23
8[5]Timothy M,Mason,Tracy G,et al. Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats[J].Diabetes,1999,48:524～530
9[6]Sako Y,Grill VE. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation[J].Endocrinology,1990,127:1580～1589
10[7]Zhou YP, Grill VE .Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose induced insulin secretion and biosynthesis through a glucose fatty acid cycle[J].J Clin Invest,1994,93:870～876
6McGarry JD. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes[ J]. Diabetes, 2010, l ( 1 ) : 87 -90.
7Cederholm J, Wiebell L. Insulin release and peripheral sensitivity at the oral glucose test[ J]. Diabet Rcs Clin Pract, 2010, 1 ( 1 ) : 1121 - 1122.
8Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin se- cretion and increased insulin resistance are independently related to the 7 - day risk of NIDDM in Mexican - Americans[ J]. Diabetes, 2013, 1(l): 87-89.
9Groop LC, Saloranta C, Shank M, et al. The role of free fatty acid metabolism in the pathogensis of insulin resistance in obesity and non insulin - dependent diabetes mellitus [ J ]. J Clin Endocrinol, 2014, 4(25) : 45 -47.
