摘要
目的探讨位于CD14基因启动子区域的C260T多态等位基因变异体CD14启动子区域-260位点C、T等位基因[CD14C(-260)T]启动子多态性对冠心病患者C反应蛋白水平的影响。方法通过研究82例稳定性冠心病患者的高敏C反应蛋白(hs-CRP)水平检测组织炎症。结果CD14基因中C260T多态性基因型分布如下:CC18例(22%)、TC48例(58.5%)、TT16例(19.5%)。相比于其它等位基因携带者TT型个体具有较高的hs-CRP(P=0.04)。具有较高百分比的T等位基因纯合子其hs-CRP>0.3mg/dl(P=0.01)。结论功能多态性的T纯合子在缺血性危险中是增高的,与hs-CRP>0.3mg/dl是独立相关的(P=0.004)。
Object To assess the influence of the CD14 C（-260）T promoter polymorphism located in the promoter region of the CD14 gene on C-reactive protein levels in patients with coronary artery disease. Methods Highsensitivity C-reactive protein （hs-CRP） was used as a measurement of systemic inflammation in Eighty-two patients with stable coronary artery disease. Results The genotype distribution of the C260T polymorphism of the CD14 gene was as follows： CC in 18 of 82 patients （22%）, TC in 48 of 82 patients （58.5%）, and TT in 16 of 82 patients （19.5%）. TT subjects had increased hs-CRP levels compared with carriers of the C allele （P=0.04）. A higher percentage of T allele homozygotes had hs-CRP levels〉0.3mg/dl （P=0.01）. Conclusions T homozygotes of this functional polymorphism are at increased ischemic risk, and it is independently associated with hs-CRP levels〉0.3mg/dl （P= 0.004）.
出处
《江西医学检验》
2007年第4期304-306,共3页
Jiangxi Journal of Medical Laboratory Sciences
关键词
CD14
C反应蛋白
冠心病
炎症
CD14
C-Reactive protein
Coronary artery disease
Inflammation
