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海洛因成瘾相关基因多态性研究进展 被引量：4

Advance of Polymorphisms in the Genes Related to Heroin Addiction
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摘要 海洛因依赖是种不顾后果的强制性寻觅和使用海洛因的行为，它不仅与心理因素和社会因素相关，还是种机制复杂的中枢神经功能失调。遗传流行病学研究表明遗传因素在海洛因依赖上起很大作用，多巴胺能神经系统和单胺能神经系统相关基因多态性与海洛因成瘾易感性有一定关系。 Heroin addiction can be considered as a loss of control heroin taking, or compulsive heroin-seeking and taking despite horrendous consequences. Although it involves many psychological and social factors, it is widely accepted that heroin addiction is a central nervous system disorder of complicated mechanisms related to dopaminergic neurons and monoaminergic neurons. Genetic epidemiologic studies support a high degree of heritable vulnerability for heroin dependence and polymorphisms in the dopaminergic- related genes and monoaminergic-related genes appear to contribute to individual risk for addiction.
作者 张恒 褚嘉祐
机构地区 中国医学科学院中国协和医科大学医学生物学研究所医学遗传室
出处 《国际遗传学杂志》 CAS 2007年第4期302-306,共5页 International Journal of Genetics
关键词 海洛因 多态性 基因 Heroin Polymorphism Gene
分类号 R74 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献25

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二级参考文献38

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共引文献44

同被引文献67

  • 1苑成梅,赵敏,方贻儒,张野,江三多,张明园.海洛因依赖与5-羟色胺受体基因多态性关联的研究[J].中国行为医学科学,2005,14(3):229-231. 被引量：8
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  • 3徐振波,王廷华,张杰,胡海洋,李晓斌,杜舟,林勇.海洛因依赖与5-HTR_(2A)基因多态性的关系[J].四川大学学报（医学版）,2005,36(6):895-896. 被引量：6
  • 4周文华,杨国栋.海洛因依赖:一种慢性脑病的临床治疗[J].中国药物滥用防治杂志,2006,12(5):251-254. 被引量：21
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引证文献4

二级引证文献8

国际遗传学杂志
2007年 第4期

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