摘要
目的探讨胃癌组织中p15、p16和nm23蛋白的表达及其相关性。方法应用免疫组织化学SP方法检测52例患者手术切除胃癌组织中p15、p16和nm23蛋白的表达水平。结果p15、p16和nm23蛋白在胃癌组织中的阳性率分别为42.3%、44.2%、40.4%;p16蛋白表达与胃癌的分化程度、淋巴结转移、肿瘤分期和患者生存期在统计学上均差异显著(P<0.05),而与胃癌的组织学类型无关(P>0.05);nm23蛋白表达与淋巴结转移、肿瘤分期和患者生存期有显著性差异(P<0.05),与胃癌的组织学类型和胃癌的分化程度无关(P>0.05);p15蛋白表达与胃癌临床病理特征无相关性(P>0.05);p15、p16和nm23蛋白在胃癌中的阳性表达两者间呈正相关(P<0.05)。结论联合检测P15、P16和nm23蛋白的表达可为临床判断胃癌生物学行为及评估预后提供客观的参考指标。
Objective To explore the expression and its relation of P15.p16 and nm23 protein in gastric cancer. Methods The expression of p15.p16 and nm23 protein was detected with immunohistochemical SP method in 52 cases gastric cancer. Results The positive expression rates of p15, p16 and nm23 were 42.3% 44.2% and 40.4% were respectively in gastric carcinoma;p16 and nm23 protein expression were significantly correlated with survival period,lymphnode metastasis and clinical pathological stage （P 〈 0.05） ,but were not related to histological type （P 〈 0.05）. there was a significant positive correlation between the expression of p16,p15and nm23 in gastric carcinoma （P 〈 0.05）. Conclusions The expression of p15, p16 and nm23 can be used to evaluate the biological behavior and prognosis of gastric cancer.
出处
《齐齐哈尔医学院学报》
2007年第10期1153-1155,F0004,共4页
Journal of Qiqihar Medical University
