摘要
目的:探讨系统性红斑狼疮(SLE)合并血小板减少的发生机制及血小板生成素(TPO)在SLE合并血小板减少诊治中的作用和意义。方法:采用双抗体夹心酶联免疫吸附法(ELISA)检测42例SLE患者、17例再生障碍性贫血(AA)患者及30例正常对照血清TPO水平。结果:SLE组血清TPO水平高于正常对照组(P<0.01),低于AA组(P<0.05)。SLE组血清TPO水平与循环免疫复合物和血沉呈正相关(P<0.01),与补体C3呈负相关(P<0.01)。结论:SLE患者TPO水平升高,并与体内的免疫和炎症反应密切相关,在SLE伴血小板减少的发生机制中具有一定意义。
Objective： To investigate the clinical importance of thrombopoietin （TPO） in the pathogenesis, diagnosis and treatment of systemic lupus erythematosus （SLE）. Methods： The serum levels of TPO were detected by enzyme-linked immunosorbent assay （ELISA） in 42 SLE patients, 17 aplastic anemia （AA） patients and 30 normal controls. Results： The serum level of TPO in SLE group was higher than that in control group （P〈 0.01 ） and lower than that in AA group （P〈 0.05 ）. The serum level of TPO was positively related to circulatory immune complex（CIC ） and erythrocyte sedimentation rate（ ESR ） （ P 〈 0.01 ） and negatively related to C3 （P 〈 0.01 ） in SLE. Conclusion： The serum level of TPO increases in SLE and relates to the immunological and inflammatory reactions. TPO has a significant effect on the pathogenesis of SLE with thrombocytopenia.
出处
《天津医药》
CAS
北大核心
2007年第7期491-493,共3页
Tianjin Medical Journal
