摘要
目的：报道２例以染色体ｔ（８；２１）为特征的四倍体克隆白血病。方法：用Ｒ显带法对２例急性髓细胞白血病Ｍ２型（ＡＭＬ－Ｍ２）患者骨髓细胞染色体核型进行分析。结果：２例患者除正常细胞外，各有３个相关异常克隆：４６，ＸＹ，ｔ（８；２１）（２％）、４６，ＸＹ，ａｄｄ（７）（ｑ３１），ｔ（８；２１）（６．８％）和９２，ＸＸＹＹ，ａｄｄ（７）（ｑ３１）×２，ｔ（８；２１）×２（８０．６％），见于例１；４６，ＸＸ，ｔ（８；２１）（１３．４％）、４７，ＸＸ，＋４，ｔ（８；２１）（４６．３％）和９４，ＸＸＸＸ，＋４×２，ｔ（８；２１）×２（３９．１％），见于例２。２例化疗后均未获完全缓解且分别生存４和６个月。结论：四倍体或近四倍体克隆与Ｍ２／ｔ（８；２１）白血病有特别的联系且为其继发性改变，通常意味着预后不良。
Objective:To report two cases of leukemia with t(8;21) and tetraploid clones.Methods:R banding technique was used.Results:Cytogenetic studies of BM cells at diagnosis revealed that each of the two cases had three related abnormal clones besides a normal one:46,XY,t(8;21)(2%),46,idem, add((7)(q31)(6.8%) and 92, idem×2(80.6%) in case 1 and 46, XX,t(8;21)(13.4%), 47, idem,+4(46.3%) and 94,idem×2(39.1%) in case 2.They did not obtain complete remission on chemotherapy and survived 4 and 6 months,respectively.Conclusion:Tetraploid or near tetraploid clones are secondary events which are specifically associated with t(8;21) leukemia and the prognosis of patients with this kind of abnormal karyotype is poor.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1997年第5期240-242,共3页
Chinese Journal of Hematology
关键词
染色体易位
四倍体
急性
白血病
Chromosome translocation Tetraploidy Leukemia,myeloid,acute
