摘要
目的探索氟西汀对慢性失眠症的治疗是否有效,同时比较氟西汀与阿普仑对慢性失眠症的治疗效果。方法将84例符合慢性失眠症诊断标准的患者随机分为氟西汀治疗组和阿普唑仑治疗组。采用匹兹堡睡眠质量指数(PSQI)及睡眠日记对睡眠质量进行评定。结果治疗的第1天、第8天,阿普唑仑组患者睡眠状况显著改善,而氟西汀组则无明显变化;治疗的第15天,氟西汀组患者睡眠状况显著改善,睡眠各项指标与治疗前及阿普唑仑组相比,差异具有统计学意义,而阿普唑仑组患者的睡眠状况又恢复到治疗前水平;治疗结束时及治疗结束后3个月,氟西汀组患者的睡眠状况依然好于治疗前及阿普唑仑组,差异具有统计学意义。结论氟西汀可以有效治疗慢性失眠症,远期效果好于阿普唑仑。
Objective To determine whether fluoxetine would be effective in the treatment of patients with chronic insomnia and to compare efficacy of fluoxetine and alprazolam on chronic insomnia. Methods 84 patients with chronic insomnia were divided into 2 groups, receiving treatments of fluoxetine and alprazolam respectively. All of the subjects were assessed with Pittsburgh Sleep Quality Index（PSQI） and sleep diary. Results On the first and eighth day of treatment,alprazolarn group showed improvement, all the indexes of sleep were better than those of before treatment and those of fluoxetine group;On the fifteenth day of treatment, fluoxetine group showed improvement,all the indexes of sleep were better than those of before treatment and those of alprazolam group,while the indexes of the alprazolam group returned to pre-treatment level;At the end of treatments and 3 months＇following up, fluoxetine group still showed better effect in sleep indexes than alprazolam group and the pre-treatment level. Conclusion Fluoxetine is effective in the treatment of chronic insomnia and shows long-term effect.
出处
《四川精神卫生》
2007年第3期150-152,共3页
Sichuan Mental Health
