期刊文献+

系统生物学研究及其在医学中的应用 被引量:5

Systems Biology and its Application in Medicine
在线阅读 下载PDF
导出
摘要 目前,系统生物学研究已初显端倪。生物学正从分子生物学走向系统生物学,由精细的分解研究转向系统的整体研究,由还原论的研究方法过渡到系统论的研究方法。简要论述了系统生物学的产生背景、结构和内容、研究思路和方法、与医学的关系等,重点介绍系统生物学的内容和研究方法,以及在疾病治疗和药物开发中的研究进展。 The research of systems biology is at the beginning of its inkling in recent times. Biological researches are turn from the molecular biology studies to systems-oriented biological researches. The research methods are also undergoing a change from detailed breakdown analysis to systematic integrated analysis, from analysis theory to system theory. In this review, systems biology from aspects of its developing background, structure and contents, research thought and method, its relationship with medicine as well as its application perspective were discussed, mainly focused in the contents, the research methods and research progress in disease therapy and drug discovery.
出处 《生物技术通讯》 CAS 2007年第4期723-726,共4页 Letters in Biotechnology
关键词 系统生物学 疾病治疗 药物开发 systems biology disease therapy drug discovery
  • 相关文献

参考文献29

  • 1Hartwell LH,Hopfield J,Leibler S,et al.From molecular to modular cell biology[J].Nature,1999,402(6761 Suppl):C47.
  • 2Ravasz E,Somera AL,Mongru DA,et al.Hierarchical organization of modularity in metabolic networks[J].Science,2002,97(5586):1551.
  • 3Ihmels J,Friedlander G,Bergmann S,et al.Revealing modular organization in the yeast transcriptional network[J].Nat Genet,2002,31 (4):370.
  • 4Tanay A,Sharan R,Kupiec M,et al.Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data[J].Proc Natl Acad Sci USA,2004,101 (9):2981.
  • 5Bhalla US,Iyenger R.Robustness of the bistable behavior of a biological signaling feedbackloop[J].Chaos,2001,11:221.
  • 6Milo R,Shen-Orr S,Itzkovitz S,et al.Network motifs:simple building blocks of complex networks[J].Science,2002,298(5594):824.
  • 7Barkai N,Leibler S.Robustness in simple biochemical networks[J].Nature,1997,387:913.
  • 8Shen-Orr SS,Milo R,Mangen S,et al.Network motifs in the transcriptional regulation network of Escherichia coli[J].Nat Genet,2002,31:646.
  • 9Foe VE,Field CM,Odell GM,et al.Microtubes and mi totic cycle phase modulate spatiotemporal distributions of faction and myosin Ⅱ in Drosophila syncytial blastoderm embryo[J].Development,2000,127:1767.
  • 10Staudt LM.Gene expression physiology and pathophysiology of the immune systems[J].Trends Immunol,2001,22:35.

同被引文献52

引证文献5

二级引证文献47

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部