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一例伴有t(4;12)(q11;q13)的急性髓系/NK细胞白血病的临床和实验研究 被引量：2

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摘要 急性早幼粒细胞白血病（APL）是急性髓系白血病（AML）中一种独特的亚型。临床上常有DIC所致的出血倾向，细胞形态学上以外周血和骨髓中含嗜天青颗粒的早幼粒细胞显著增生伴交织状Auer小体为特征，免疫表型分析显示CD13和CD33强阳性而CD34和HLA—DR阴性。
作者 仇惠英 薛永权 潘金兰 吴亚芳 张俊 马勤芬 岑建农
机构地区 苏州大学附属第一医院
出处 《中华血液学杂志》 CAS CSCD 北大核心 2007年第7期489-491,共3页 Chinese Journal of Hematology
基金 卫生部基金(WKJ2005-2-025)
关键词 急性髓系白血病 NK细胞白血病 急性早幼粒细胞白血病 实验研究 临床 AUER小体 免疫表型分析 嗜天青颗粒
分类号 R733.7 [医药卫生—肿瘤]
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参考文献10

  • 1Redner RL.Variations on a theme:the alternate translocations in APL.Leukemia. 2002, 16:1927-1932.
  • 2Huang W,Sun GL,Li XS,et al.Acute promyelocytic leukemia:clinical relevance of two major PML-RAR alpha isoforms and detection of minimal residual disease by retrotranscriptase/polymerase chain reaction to predict relapse.Blood,1993,82:1264-1269.
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同被引文献21

  • 1许莲蓉,苏丽萍,朱镭,乔振华,杨林花,马梁明.髓系/NK细胞急性白血病一例[J].中华内科杂志,2007,46(8):636-636. 被引量：2
  • 2I_o-Coco F,Ammatuna E, Montesinos P,et al. Acute promyelocytic leukemia: recent advances in diagnosis and management. Semi On- col,2008 ;35(4) :401 -409.
  • 3Scott AA, Head DR, Kopecky KJ, et al. HLA-DR- , CD33 ^+, CD56^+ , CD16^- myeloid/natural killer cell acute leukemia: A previ- ously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood, 1994; 84( 1 ) :244 - 256.
  • 4Rubio-Batll6s M, de la Mata AC, Macias JRR, et al. Isolated a- symptomatic severe neutropenia as the presentation of myeloid/natu- ral killer cell acute leukemia. Haematologiea, 2000 ; 85 ( 3 ) : 322 - 323.
  • 5Burgaleta C, de Mignel D, Rubio ML, et al. Myeloid natural killer cell leukemia resembling a variant of acute promyelocytie leukemia. Haematologica, 2001 ; 86 ( 7 ) : 765 - 766.
  • 6Sun T, Pashaei S, Jaffrey I, et al. A hybrid form of myeloid/NK-cell acute leukemia and myeloid/NK-eell precursor acute leukemia. Hu- man Pathol,2003 ;34(5) :504-508.
  • 7Tang G,Truong F, Fadare O, et al. Diagnostic challenges related to myeloid/natural killer cells, a variant of myeloblasts. Int J Clin Exp Patho1,2008 ; 1 (6) :544 - 549.
  • 8Chen B,Xu X,Ji M,et al. Myeloid/NK cell acute leukemia. Int J Hemato1,2009 ;89 ( 3 ) :365 - 367.
  • 9Lee JJ, Kim HJ, Cghung U,et al. Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. Leuk Lymphoma, 2001 ;41 (3 -4) :457 -460.
  • 10Oshimi K. Progress in understanding and managing natural kill-cell malignancies. Br J Haematol,2007 ; 139 (4) :532 - 544.

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中华血液学杂志
2007年 第7期

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