摘要
目的：探讨2型糖尿病（T2DM）患者血浆FGF-21水平变化及其与体重指数（BMI）、腰臀比（WHR）、血糖、血浆胰岛素水平等的关系。方法：采用放射免疫法测定了T2DM患者及正常人血浆FGF-21水平，并分析了血浆FGF-21水平与BMI、WHR、胰岛素抵抗指数（HOMA—IR）、胰岛β细胞分泌指数（HOMA—IS）、血脂、血糖、血浆胰岛素和游离脂肪酸（FFA）水平等的关系。结果：T2DM患者血浆FGF-21水平明显高于对照组（1．82±0．64VS1．53±0．60ng／L，P〈0．05）。血浆FGF-21水平与FFA、HOMA—IS呈明显正相关（r=0．36，r=0．33，均P〈0．05），与WHR、空腹血糖（FBG）、负荷后2h血糖（2hPBG）呈明显负相关（r=-0．23，r=-0．39，r=-0．28，均P〈0．05）。多元回归分析表明腰臀比（WHR）是影响血浆FGF-21水平的独立相关因素。结论：血浆FGF-21水平的改变与代谢紊乱有关．并可能参与了T2DM的发生和发展。
Objective：To investigate the changes of plasma FGF-21 levels and the relationship between plasma FGF-21 levels and body mass index（BMI）, waist hip ratio（WHR）, blood glucose, plasma insulin levels as well as other factors in newly diagnosed type 2 Diabetic mellitus （T2DM）. Methods：Plasma FGF-21 levels were assayed by ILIA in the patients with T2DM and in the controls. The relationship between plasma FGF-21 levels and BMI, HOMA-IR, HOMA-IS, blood lipids, plasma glucose, insulin, free fatty acids （FFA） levels were also analyzed. Results：Plasma FGF-21 levels in patients with T2DM were significantly increased compared with controls （1.82± 0.64 vs 1.53±0.60 ng/L,P 〈 0.05）. Plasma FGF-21 levels correlated positively with FFA, HOMA-IS （r=0.36, r=0.33, all P〈0.05）, and negatively with WHR, FBG and 2hPBG （r=-0.232, r=-0.385, r=-0.276, all P〈 0.05）. Multiple regression analysis showed that WHR was independent related factor influencing plasma FGF-21 levels. Conclusion ：The changes of FGF-21 levels are associated with metabolism disorder, and it may contribute, partly to the pathogenesis of T2DM.
基金
国家自然科学基金项目（30270631,30370671）
国家教委春晖计划资助项目（2003-56）美国NIH基金项目（R01HL073267,DK066003）
