摘要
目的：探讨非那雄胺对良性前列腺增生组织VEGF、Fit-1表达和MVD计数的影响。方法：将前列腺增生患者按术前是否服用非那雄胺分为服药组和对照组，采用免疫组织化学S-P法，检测前列腺组织VEGF、Fit-1表达和MVD计数。结果：服药组VEGF阳性表达率为68．4％；对照组VEGF阳性表达率为57％，两组有显著性差异（p〈0．05）。服药组与对照组Flt-1表达全部为阳性。服药组MVD值为6．89±2．54；对照组MVD值为9．17±3．63，两组有显著性差异（p〈0．05）。结论：服用非那雄胺后可减少前列腺增生组织VEGF的合成、抑制微血管的形成，而对Flt-1无明显影响。
Objective：To study the effect of finasteride on the expression of VEGF,Flt-1 and the MVD in benign prostatic hyperplasia. Methods：BPH cases was divided into 2 groups; finaster/de treatment group and non.Immtmohistochemical staining（S-P） was used to examine MVD and the expression of VEGF,Flt-1 in BPH. Results：The positive rate of VEGF in the treatment group was 68.4%; the positive rate of VEGF in the non treatment group was 57%. Statistic significance existed between the two groups （P〈0.05）. The expression of Flt-1 was all positive . MVD was 6.89±2.54 in finasteride treated group and 9.17±3.63 in nontreatment group. Statistic significance of both VEGF and MVD expression existed in the two groups（P〈0.05）. Conclusions： Finasteride could downregulate the synthesis and expression of VEGF, which inhibit the angiogenesis in BPH, but has less impact on Flt-1.
