摘要
目的观察食管癌组织ＩＬ－２Ｒ的表达和患者血清ＳＩＬ－２Ｒ的变化，探讨ＩＬ－２Ｒ和ＳＩＬ－２Ｒ与食管癌发生、发展的关系。方法采用双抗体夹心ＥＬＩＳＡ法对４２例食管癌患者血清可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）水平进行测定，同时应用即用型ＳＡＢＣ免疫组织化学方法观察ＩＬ－２Ｒ在食管癌组织的表达情况。结果食管癌患者血清ＳＩＬ－２Ｒ水平显著高于正常对照组（Ｐ＜０．０５），并与临床分期有关；ＩＬ－２Ｒ在食管癌组织中阳性表达率５２．４％（２２／４２），显著高于正常食管粘膜组（Ｐ＜０．０５），并与临床分期有关。结论ＩＬ－２Ｒ表达和血清ＳＩＬ－２Ｒ水平可作为临床诊断和判断患者预后的重要参考指标。
Objective\ To examine the IL 2R expression and serum SIL 2R in patients with esophageal carcinoma and to determine the relationship between IL 2R,SIL 2R and esophageal carcinoma.Method\ Using a Sandwich enzyme linked immunosorbent assay(ELISA) and using SABC.Results\ Serum SIL 2R levels in patients were significantly higher than those of normal control and correlated with the P TNM staging (P<0.05);of 42 patients tested,22(52.4%) showed positive staining,the positive staining rate wes higher in esophageal carcinoma and correlated with the P TNM staging(P<0.05).Conclusions\ The results suggest that IL 2R expression and SIL 2R level may be closely related to diagnosis and prognosis of patients with esophageal carcinoma.
出处
《现代诊断与治疗》
CAS
1997年第2期77-78,共2页
Modern Diagnosis and Treatment
