摘要
以荧光偏振免疫方法对豚鼠肌内注射乙基西梭霉素后血浆及外淋巴的药物动力学进行研究，其药动学过程符合二室开放模型，在血浆中的主要药动学参数Ｋａ为２６．９８ｈ－１，Ｋｅ为１．４２ｈ－１，Ｔ１／２β为０．６８３ｈ，Ｔｍａｘ为０．３２５ｈ，Ｃｍａｘ为３５２．４５μｇ／ｍｌ；在外淋巴液Ｋａ为１．２９ｈ－１，Ｋｅ为０．１２６ｈ－１，Ｔ１／２β为１５．９７ｈ，Ｔｍａｘ为１．３７ｈ，Ｃｍａｘ为９．０４μｇ／ｍｌ。结果表明：乙基西梭霉素在外淋巴消除缓慢，半衰期显著大于血浆半衰期。
fter guineas were given with netilmicin 100mg·kg -1 intramuscularly,plasma and perilymph concentration of netilmicin was determined by FPIA.The concentration time curve of netilmicin in guineas was shown to fit a two compartment open model.The main pharmacokenetic parameters was K a = 26.98 h -1 , K e = 1.42 h -1 , T 1/2β = 0.683 h, T max = 0.325 h, C max = 352.45 μg/ml in plasma and K a = 1.29 h -1 , K e = 0.126 h -1 , T 1/2β = 15.97 h, T max = 1.37 h, C max = 9.04 μg/ml.The results showed that netilmicin elimiated slowly in perilymph and its half life was longer than the half life in plasma significantly.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1997年第4期150-151,共2页
Chinese Journal of Hospital Pharmacy
