摘要
内质网应激(ERS)是细胞应激的重要组成部分,表现为内质网腔内错误折叠和未折叠蛋白聚集以及细胞内Ca^(2+)平衡紊乱,与应激细胞的适应、损伤或凋亡直接相关。ERS诱发的主要信号通路有未折叠蛋白反应(UPR)、固醇调节级联反应以及凋亡信号通路。β细胞具有高度发达的内质网,对ERS极具易感性。β细胞可通过上述信号通路维持内质网稳态以求得细胞生存,但过长、过强的ERS可激活特有的凋亡通路导致β细胞的死亡。
Endoplasmic reticulum stress is one of the critical components in cell stress. Many disturbances, including the presence of misfolded and unfolded proteins in the endoplasmic reticulum （ER）, and the disturbance of Ca^2 ＋ homeostasis are sensed by cells and initiate a stress response, which is ER stress. ER stress is associated with cell adaptation, lesion and apoptosis. The cellular signaling pathways of ER stress include the unfolded protein response, sterol regulatory cascade response and apoptosis pathways. Pancreatic β cell has a highly developed ER and is particularly susceptible to ER stress, which is aimed initially at compensating for damage but can eventually trigger β cell death if ER dysfunction is severe or prolonged.
出处
《国际内分泌代谢杂志》
2007年第4期261-263,共3页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金(30500249)
关键词
内质网应激
未折叠蛋白反应
Β细胞
细胞凋亡
糖尿病
Endoplasmic reticulum stress
Unfolded protein response
β cell
Apoptosis
Diabetes meUitus
