摘要
抗癌剂２号（ＡｎｔｉｎｅｏｐｌａｓｔｏｎＡ３）是从人尿中分离提取的一种含肽类的氧化物。小鼠ｉｐ抗癌剂２号的ＬＤ５０为２．０１±０．２６ｇ·ｋｇ－１，当ｉｐＬＤ５０或大于ＬＤ５０（２．５ｇ·ｋｇ－１）的抗癌剂２号时，可见小鼠对机械刺激的反应降低，自主活动明显减少，小鼠肌张力及协调平衡活动呈明显障碍，提示抗癌剂２号的急性毒性主要表现在神经系统。
Antineoplaston A 3 is an oxidized mixture of peptide derivatives isolated from human urine. The LD 50 of Antineoplaston A 3 is 2 01±0 26 g·kg -1 in the mice by ip. When Antineoplaston A 3 is injected (ip) into the mice at the dosage of LD 50 or more(2 5 g·kg -1 ) it is found that the response for machinery stimulation, the autonomic activity, the muscle tone and the regulation of balance ability decreased obviously. It is indicated that Antineoplaston A 3 could be toxie to the nervous system of mice. MeSH antitumor agents/pharmacology; antitumor agents/toxicity
出处
《安徽医科大学学报》
CAS
1997年第2期101-102,共2页
Acta Universitatis Medicinalis Anhui
