摘要
目的分析幽门螺杆菌对6种临床使用抗生素的耐药率,为临床选用抗生素治疗幽门螺杆菌提供依据。方法2006年3月～2007年2月期间共采集3304例患者胃镜检查后活检组织做幽门螺杆菌培养,采用Kiby-bauer法对幽门螺杆菌阳性分离菌株进行甲硝唑、阿莫仙、庆大霉素、左氧氟沙星、呋喃唑酮和克拉霉素6种抗生素药敏试验。结果3304例临床标本中幽门螺杆菌培养阳性为1171例,占35.4%;药敏试验结果显示甲硝唑耐药率最高,达99.32%;左氧氟沙星耐药率最低,仅0.51%,在12个月时间内的两种抗生素耐药率无明显变化;阿莫仙、庆大霉素、呋喃唑酮和克拉霉素均存在不同程度的耐药,耐药率分别为61.06%、4.78%、21.35%和39.45%,且在12个月内的耐药趋势均有明显变化。结论随着根治幽门螺杆菌时抗生素的应用,幽门螺杆菌的抗生素耐药率逐年上升,甲硝唑的耐药率最高;药敏试验对临床幽门螺杆菌菌株的根治具有一定参考作用。
Objective To investigate the antibiotic resistance rate of Helicobacter pylori, and to provide reliable evidence of choo- sing optimal drugs for clinical therapy. Methods Overall 3304 patients were enrolled from February 2006 to March 2007 who accepted gastroscopy followed by Helicobacter pylori culture of the gastric mucosa from biopsy. The antimicrobial susceptibilities of Helicobacter pylori strains for six antibiotics including metronidazole, amoxicilin, gentamycin, levofloxacin, furazolidone, clarithromycin were observed by Kirby - Bauer disk diffusion test. Results 1171 （35.4%） biopsy clinical specimens were proved to be Helicobacter pylori positive when cultured in vitro and identified by conventional assays. The metronidazole resistance rate （99.32%） of Helicobacter pylori was significantly higher than that of any of the other 5 antibiotics, and the levofloxacin resistance rate （0.51% ） was the lowest. Furthermore there were no significantly change in the tendency of resistance rate for the two above antibiotics from February 2006 to March 2007. How- ever, Helicobacter pylori was resistant to amoxicilin, gentamycin, furazolidone, clarithromycin, and the resistance rate was 61.06% ,4. 78% ,21.35% and 39.45% respectively. Meanwhile, the resistance rates corresponding to four antibiotics were different obviously. Conclusions With the application of antibiotics for Helicobacter pylori eradication, the antibiotic resistance rate increased perceptibly. The rate of resistance to metronidazole appeared to be the highest among six antibiotics applied to clinical treatment. Drug susceptibility testing was valuable to eradicate Helicobacter pylori in clinical therapy.
出处
《医学研究杂志》
2007年第7期98-100,共3页
Journal of Medical Research
关键词
幽门螺杆菌
抗生素
耐药性
Helicobacter pylori
Antibiotic
Antibiotic resistance rate
